Asymptomatic patients as a source of COVID-19 infections: A systematic review and meta-analysis

dc.creatorKronbichler, Andreas
dc.creatorKresse, Daniela
dc.creatorYoon, Sojung
dc.creatorLee, Keum Hwa
dc.creatorEffenberger, Maria
dc.creatorShin, Jae Il
dc.date.accessioned2020-07-23T14:57:14Z
dc.date.available2020-07-23T14:57:14Z
dc.date.created2020-06-17
dc.description.abstractenglishBackground Coronavirus Disease 2019 (COVID-19) is characterised by an unpredictable disease course, ranging from asymptomatic infections to severe, life-threating manifestations. Asymptomatic COVID-19 infections have been described, and the aim of this systematic review was to summarise their presentation form. Methods We searched PubMed® and Google® (1 December 2019 to 29 March 2020) and extracted age, laboratory findings, and computed tomography (CT) investigations. Pooled incidence rates of clinical characteristics were analysed using random effects models. Results In total, 506 patients from 34 studies (68 single cases and 438 from case series) with an asymptomatic course were identified. Patients with normal radiology were younger (19.59 ± 17.17 years) than patients with abnormal radiology (39.14 ± 26.70 years) (p value = 0.013). Despite being asymptomatic, CT investigations revealed abnormalities in 62.2% of the cases and ground glass opacities were most frequently observed (43.09% by meta-analysis). Most studies reported normal laboratory findings (61.74% by meta-analysis). Conclusions More than half of patients without any symptoms present with CT abnormalities. Asymptomatic patients may be contagious and thus a potential source of transmission of COVID-19.spa
dc.format.extent26 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1016/j.ijid.2020.06.052spa
dc.identifier.issn1201-9712spa
dc.identifier.otherhttps://www.sciencedirect.com/science/article/pii/S1201971220304872#kwd0005spa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/11022
dc.publisherScience Directeng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCOVID-19spa
dc.subject.keywordCoronavirus disease-19 (COVID-19)spa
dc.subject.keywordSARS-CoV-2spa
dc.subject.keywordAsymptomaticspa
dc.subject.keywordMeta-analysisspa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titleAsymptomatic patients as a source of COVID-19 infections: A systematic review and meta-analysisspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

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