Fibrinolysis shut down in COVID-19 patients: Report on two severe cases with potential diagnostic and clinical relevance
| dc.creator | Bakchoul, Tamam | |
| dc.creator | Hammer, Stefanie | |
| dc.creator | Lang, Peter | |
| dc.creator | Rosenberger, Peter | |
| dc.date.accessioned | 2020-09-21T14:18:46Z | |
| dc.date.available | 2020-09-21T14:18:46Z | |
| dc.date.created | 2020-06-23 | |
| dc.description.abstractenglish | Dear Sirs Accumulating evidence indicates an association between 2019-nCoV pneumonia and disseminated intravascular coagulation (DIC) [1,2]. Although some controversy exists about the extent of DIC in COVID-19 [3], DIC was indicated to be a strong predictor of mortality in patients developing pneumonia with this virus [1,2,4]. The pathophysiology of infection associated-DIC is complex and multifactorial, involving interplay between cellular and plasmatic elements of the hemostatic system and components of the innate immune response to the infecting pathogen [4,5]. In this letter, we report on the viscoelastic properties of clots formed by COVID-19 patients. Using a novel method to assess clot formation a fibrinolysis shut down was observed. This finding has not been reported yet in COVID-19 infection and suggests that fibrinolysis system significantly contributes to the procoagulatory status in COVID-19 patients and might represent a therapeutic target. | spa |
| dc.format.extent | Thrombosis Update | spa |
| dc.format.mimetype | application/pdf | spa |
| dc.identifier.doi | https://doi.org/10.1016/j.tru.2020.100008 | spa |
| dc.identifier.other | https://www.sciencedirect.com/science/article/pii/S2666572720300080?via%3Dihub | spa |
| dc.identifier.uri | https://hdl.handle.net/20.500.12010/13494 | |
| dc.language.iso | spa | spa |
| dc.rights.accessrights | info:eu-repo/semantics/restrictedAccess | spa |
| dc.rights.local | Acceso restringido | spa |
| dc.source | reponame:Expeditio Repositorio Institucional UJTL | spa |
| dc.source | instname:Universidad de Bogotá Jorge Tadeo Lozano | spa |
| dc.subject | Fibrinolysis | spa |
| dc.subject | Coagulation | spa |
| dc.subject.lemb | Síndrome respiratorio agudo grave | spa |
| dc.subject.lemb | COVID-19 | spa |
| dc.subject.lemb | SARS-CoV-2 | spa |
| dc.subject.lemb | Coronavirus | spa |
| dc.title | Fibrinolysis shut down in COVID-19 patients: Report on two severe cases with potential diagnostic and clinical relevance | spa |
| dc.type.coar | http://purl.org/coar/resource_type/c_6501 | spa |
| dc.type.hasversion | info:eu-repo/semantics/acceptedVersion | spa |
| dc.type.local | Artículo | spa |
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