Meta-Analysis of coagulation parameters associated with disease severity and poor prognosis of COVID-19

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dc.creatorZhang, Aining
dc.creatorLeng, Yan
dc.creatorZhang, Yi
dc.creatorWu, Kefan
dc.creatorJi, Yelong
dc.creatorLei, Shaoqing
dc.creatorXia, Zhongyuan
dc.date.accessioned2020-09-18T01:25:35Z
dc.date.available2020-09-18T01:25:35Z
dc.date.created2020-09-15
dc.description.abstractenglishBackground To figure out whether abnormal coagulation parameters are associated with disease severity and poor prognosis in patients with 2019 Corona Virus Disease (COVID-19). Methods A systematic literature search was conducted using the databases PubMed, Embase, and Web of sciences until April 25, 2020. We included a total of 15 studies with 2277 patients. Platelet count (PLT), prothrombin time (PT), activated partial thromboplastin time (APTT), D-dimer (D-D) and fibrinogen (FIB) were collected and analyzed. The statistical results were expressed the effect measure by mean difference (MD) with the related 95% confidence interval (CI). Results The PLT level of severe patients was lower than that of mild patients, while the levels of PT, D-D and FIB were higher than those of mild patients (P < 0.05). The level of APTT had no statistical difference between two groups (P > 0.05). Compared to Non-ICU patients, PT of ICU patients was significantly longer (P < 0.05). In Non-survivors, PT and D-D were higher, yet PLT was lower than survivors (P < 0.05). There was no significant difference in APTT between survivors and Non-survivors (P > 0.05). The funnel plot and Egger's Regression test demonstrated that there was no publication bias. Conclusions Our data support the notion that coagulopathy could be considered as a risk factor for disease severity and mortality of COVID-19, which may help clinicians to identify the incidence of poor outcomes in COVID-19 patients.spa
dc.format.extent24 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1016/j.ijid.2020.09.021spa
dc.identifier.issn1201-9712spa
dc.identifier.otherhttps://www.sciencedirect.com/science/article/pii/S1201971220307372spa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/13416
dc.language.isoengspa
dc.publisherInternational Journal of Infectious Diseasesspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.localAbierto (Texto Completo)spa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCoronavirusspa
dc.subject.keywordCoagulation parametersspa
dc.subject.keywordCoagulopathyspa
dc.subject.keywordLaboratoryspa
dc.subject.keywordPrognosisspa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titleMeta-Analysis of coagulation parameters associated with disease severity and poor prognosis of COVID-19spa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

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