CD1- and MR1-restricted T Cells in Antimicrobial Immunity

Mansour Haeryfar, S.M.; Mallevaey, Thierry

doi:10.3389/978-2-88919-750-7

CD1- and MR1-restricted T Cells in Antimicrobial Immunity

dc.creator	Mansour Haeryfar, S.M.
dc.creator	Mallevaey, Thierry
dc.date.accessioned	2020-10-22T20:07:13Z
dc.date.available	2020-10-22T20:07:13Z
dc.date.created	2016-04-07
dc.description.abstractenglish	Cell-mediated immunity to extracellular and intracellular microbes has been traditionally linked to CD4+ and CD8+ T cells that recognize pathogen-derived peptides in the context of major histocompatibility complex (MHC) class II and class I molecules, respectively. Recent progress in our understanding of early host defense mechanisms has brought ‘unconventional’, innate-like T cells into the spotlight. These are a heterogeneous population of non-MHC-restricted T cells that exhibit ‘memory-like’ properties and mount emergency responses to infection. They may directly detect and destroy infected cells, but are best known for their ability to regulate downstream effector cells including but not limited to conventional T cells. Innate-like T cells include among others CD1-restricted natural killer T (NKT) cells and MR1-restricted mucosa-associated invariant T (MAIT) cells. NKT cells recognize lipid antigens, and MAIT cells were recently demonstrated to respond to microbe-derived vitamin B metabolites. However, much remains to be learned about the antigen specificity range of these cells, their activation mode and their true potentials in immunotherapeutic applications. Like in many other areas of biology, uncertainties and controversies surrounding these cells and some of the experimental models, techniques and reagents employed to study them have brought about excitement and sometimes hot debates. This Special Topic was launched to provide updated reviews on protective and/or pathogenic roles of NKT and MAIT cells during infection. Leading experts discuss current controversies, pressing questions and the challenges that lie ahead for the advancement of this intriguing and rapidly evolving area of immunology. Unlike MHC, CD1 and MR1 display very limited polymorphism. Therefore, NKT and MAIT cells may be considered attractive targets for various diseases in diverse human populations. The potential benefits of NKT cell- and MAIT cell-based vaccination and treatment strategies in infectious diseases is an important subject that is also covered in this Topic.	spa
dc.format.extent	191 páginas	spa
dc.format.mimetype	application/pdf	spa
dc.identifier.doi	10.3389/978-2-88919-750-7
dc.identifier.isbn	978-2-889-19750-7
dc.identifier.issn	1664-8714
dc.identifier.other	https://www.frontiersin.org/research-topics/2874/cd1--and-mr1-restricted-t-cells-in-antimicrobial-immunity
dc.identifier.uri	https://hdl.handle.net/20.500.12010/14787
dc.language.iso	eng	spa
dc.publisher	Frontiers Media SA	spa
dc.relation.references	Haeryfar, S.M., Mallevaey, T., eds. (2016). CD1- and MR1-Restricted T Cells in Antimicrobial Immunity. Lausanne: Frontiers Media. doi: 10.3389/978-2-88919-750-7
dc.rights.accessrights	info:eu-repo/semantics/openAccess	spa
dc.rights.creativecommons	https://creativecommons.org/licenses/by/4.0/legalcode
dc.rights.local	Abierto (Texto Completo)	spa
dc.subject	Medicina	spa
dc.subject.lemb	Inmunidad	spa
dc.subject.lemb	Inmunopatología	spa
dc.subject.lemb	Infección	spa
dc.title	CD1- and MR1-restricted T Cells in Antimicrobial Immunity	spa
dc.type.coar	http://purl.org/coar/resource_type/c_2f33	spa
dc.type.local	Libro	spa

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