Relationship between chest CT manifestations and immune response in COVID-19 patients

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dc.creatorHe, Susu
dc.creatorZhou, Chao
dc.creatorLu, Dongqing
dc.creatorYang, Haihua
dc.creatorXu, Hailing
dc.creatorWu, Guixian
dc.creatorPan, Weijia
dc.creatorZhu, Rui
dc.creatorJia, HaiJian
dc.creatorTang, Xinni
dc.creatorChen, Xi
dc.creatorWu, Xiaomai
dc.date.accessioned2020-07-24T20:34:00Z
dc.date.available2020-07-24T20:34:00Z
dc.date.created2020-06-17
dc.description.abstractenglishObjectives To study the correlations of lymphocytes and cytokines between changes of lung lesion volumes in patients with COVID-19, and to predict these correlations. Methods 93 patients with COVID-19 were divided into mild and severe groups. The data of lymphocyte subgroups and cytokines were collected, the imaging characteristics were measured, and correlation analysis was performed to analyze the differences. Results 60 mild and 33 severe patients were included. Lymphocyte subsets decreased in both groups. The reduction percentages of the absolute lymphocytes value in mild and severe groups were 32% and 64%, respectively. The lung CT lesion volume of all patients was 241.45 ± 282.92 cm3, among which the mild group was 151.29 ± 226.04 cm3, and the severe group was 405.38 ± 304.90 cm3, respectively. In critically ill patients, the decrease of the absolute value of CD4+ T cells and the increase of IL-6 levels are significantly correlated with the volume of lung lesions. Conclusions The absolute values of CD3+, CD4+, and CD8+ T cells are lower in patients with COVID-19, while the levels of IL-6 and IL-10 are increased. The severity of lung lesions predicts poor clinical outcomes and may be a predictor of the transition from mild to severe.spa
dc.format.extent18 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1016/j.ijid.2020.06.059spa
dc.identifier.issn1201-9712spa
dc.identifier.otherhttps://www.sciencedirect.com/science/article/pii/S120197122030494X#kwd0005spa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/11125
dc.publisherInternational Journal of Infectious Diseaseseng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subject2019 novel coronavirusspa
dc.subjectLymphocyte subsetsspa
dc.subjectCytokinesspa
dc.subjectRadiologyspa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titleRelationship between chest CT manifestations and immune response in COVID-19 patientsspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

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