PI3K signalling

Okkenhaug, Klaus; Turner, Martin; Gold, Michael R.

doi:10.3389/978-2-88919-419-3

PI3K signalling

dc.creator	Okkenhaug, Klaus
dc.creator	Turner, Martin
dc.creator	Gold, Michael R.
dc.date.accessioned	2020-10-14T22:20:47Z
dc.date.available	2020-10-14T22:20:47Z
dc.date.created	2015-12-10
dc.description.abstractenglish	The PI3Ks control many key functions in immune cells. PI3Ks phosphorylate PtdIns(4,5)P2 to yield PtdIns(3,4,5)P3. Initially, PI3K inhibitors such as Wortmannin, LY294002 and Rapamycin were used to establish a central role for Pi3K pathway in immune cells. Considerable progress in understanding the role of this pathway in cells of the immune system has been made in recent years, starting with analysis of various PI3K and Pten knockout mice and subsequently mTOR and Foxo knockout mice. Together, these experiments have revealed how PI3Ks control B cell and T cell development, T helper cell differentiation, regulatory T cell development and function, B cell and T cell trafficking, immunoglobulin class switching and much, much more. The PI3Kd inhibitor idelalisib has recently been approved for the treatment of B cell lymphoma. Clinical trials of other PI3K inhibitors in autoimmune and inflammatory diseases are also in progress. This is an opportune time to consider a Research Topic considering when what we have learned about the PI3K signalling module in lymphocyte biology and how this is making an impact on clinical immunology and haematology.	spa
dc.format.extent	140 páginas	spa
dc.format.mimetype	application/pdf	spa
dc.identifier.doi	10.3389/978-2-88919-419-3
dc.identifier.isbn	978-2-889-19419-3
dc.identifier.issn	1664-8714
dc.identifier.other	https://www.frontiersin.org/research-topics/568/pi3k-signalling
dc.identifier.uri	https://hdl.handle.net/20.500.12010/14463
dc.language.iso	eng	spa
dc.publisher	Frontiers Media SA	spa
dc.relation.references	Okkenhaug K, Turner M and Gold MR (2014) PI3K signaling in B cell and T cell biology. Front. Immunol. 5:557. doi: 10.3389/fimmu.2014.0055. This article was submitted to T Cell Biology, a section of the journal Frontiers in Immunology.	spa
dc.rights.accessrights	info:eu-repo/semantics/openAccess	spa
dc.rights.creativecommons	https://creativecommons.org/licenses/by/4.0/legalcode
dc.rights.local	Abierto (Texto Completo)	spa
dc.subject	Medicina	spa
dc.subject.lemb	Transducción de señales	spa
dc.subject.lemb	Inhibidores de la vía PI3K	spa
dc.title	PI3K signalling	spa
dc.type.coar	http://purl.org/coar/resource_type/c_2f33	spa
dc.type.local	Libro	spa

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Facultad de Ciencias Naturales e Ingeniería