Phase-adjusted estimation of the number of Coronavirus Disease 2019 cases in Wuhan, China

dc.creatorWang, Huwen
dc.creatorWang, Zezhou
dc.creatorDong, Yinqiao
dc.creatorChang, Ruijie
dc.creatorXu, Chen
dc.creatorYu, Xiaoyue
dc.creatorZhang, Shuxian
dc.creatorTsamlag, Lhakpa
dc.creatorShang, Meili
dc.creatorHuang, Jinyan
dc.creatorWang, Ying
dc.creatorXu, Gang
dc.creatorShen, Tian
dc.creatorZhang, Xinxin
dc.creatorCai, Yong
dc.date.accessioned2020-08-25T14:27:56Z
dc.date.available2020-08-25T14:27:56Z
dc.date.created2020-02-24
dc.description.abstractenglishAn outbreak of clusters of viral pneumonia due to a novel coronavirus (2019-nCoV/SARS-CoV-2) happened in Wuhan, Hubei Province in China in December 2019. Since the outbreak, several groups reported estimated R0 of Coronavirus Disease 2019 (COVID-19) and generated valuable prediction for the early phase of this outbreak. After implementation of strict prevention and control measures in China, new estimation is needed. An infectious disease dynamics SEIR (Susceptible, Exposed, Infectious, and Removed) model was applied to estimate the epidemic trend in Wuhan, China under two assumptions of Rt. In the first assumption, Rt was assumed to maintain over 1. The estimated number of infections would continue to increase throughout February without any indication of dropping with Rt = 1.9, 2.6, or 3.1. The number of infections would reach 11,044, 70,258, and 227,989, respectively, by 29 February 2020. In the second assumption, Rt was assumed to gradually decrease at different phases from high level of transmission (Rt = 3.1, 2.6, and 1.9) to below 1 (Rt = 0.9 or 0.5) owing to increasingly implemented public health intervention. Several phases were divided by the dates when various levels of prevention and control measures were taken in effect in Wuhan. The estimated number of infections would reach the peak in late February, which is 58,077–84,520 or 55,869–81,393. Whether or not the peak of the number of infections would occur in February 2020 may be an important index for evaluating the sufficiency of the current measures taken in China. Regardless of the occurrence of the peak, the currently strict measures in Wuhan should be continuously implemented and necessary strict public health measures should be applied in other locations in China with high number of COVID-19 cases, in order to reduce Rt to an ideal level and control the infection.spa
dc.format.extent8 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1038/s41421-020-0148-0spa
dc.identifier.issn2056-5968spa
dc.identifier.otherhttps://www.nature.com/articles/s41421-020-0148-0spa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/12215
dc.language.isoengspa
dc.publisherCell Discoveryspa
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccessspa
dc.rights.localAcceso restringidospa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCoronavirus Disease 2019 casesspa
dc.subjectCovid-19 -Wuhan Chinaspa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titlePhase-adjusted estimation of the number of Coronavirus Disease 2019 cases in Wuhan, Chinaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

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