Brain abnormalities in COVID-19 acute/subacute phase: A rapid systematic review
| dc.creator | Egbert, Anna Rita | |
| dc.creator | Cankurtaran, Sadiye | |
| dc.creator | Karpiak, Stephen | |
| dc.date.accessioned | 2020-08-21T01:34:55Z | |
| dc.date.available | 2020-08-21T01:34:55Z | |
| dc.date.created | 2020-07-17 | |
| dc.description.abstractenglish | Objective This systematic review aimed to synthesize early data on typology and topography of brain abnormalities in adults with COVID-19 in acute/subacute phase. Methods We performed systematic literature search via PubMed, Google Scholar and ScienceDirect on articles published between January 1 and July 05, 2020, using the following strategy and key words: ((covid[Title/Abstract]) OR (sars-cov-2[Title/Abstract]) OR (coronavirus[Title/Abstract])) AND (brain[Title/Abstract]). A total of 286 non-duplicate matches were screened for original contributions reporting brain imaging data related to SARS-Cov-2 presentation in adults. Results The selection criteria were met by 26 articles (including 21 case reports, and 5 cohort studies). The data analysis in a total of 361 patients revealed that brain abnormalities were noted in 124/361 (34%) reviewed cases. Neurologic symptoms were the primary reason for referral for neuroimaging across the studies. Modalities included CT (-angiogram, -perfusion, -venogram), EEG, MRI (-angiogram, functional), and PET. The most frequently reported brain abnormalities were brain white matter (WM) hyperintensities on MRI 66/124 (53% affected cases) and hypodensities on CT (additional 23% affected cases), followed by microhemorrhages, hemorrhages and infarcts, while other types were found in <5% affected cases. WM abnormalities were most frequently noted in bilateral anterior and posterior cerebral WM (50% affected cases). Conclusion About a third of acute/subacute COVID-19 patients referred for neuroimaging show brain abnormalities suggestive of COVID-19-related etiology. The predominant neuroimaging features were diffuse cerebral WM hypodensities / hyperintensities attributable to leukoencephalopathy, leukoaraiosis or rarefield WM. | spa |
| dc.format.extent | 12 Páginas | spa |
| dc.format.mimetype | application/pdf | spa |
| dc.identifier.doi | https://doi.org/10.1016/j.bbi.2020.07.014 | spa |
| dc.identifier.issn | 0889-1591 | spa |
| dc.identifier.other | https://www.sciencedirect.com/science/article/pii/S0889159120312538 | spa |
| dc.identifier.uri | https://hdl.handle.net/20.500.12010/12056 | |
| dc.language.iso | eng | spa |
| dc.publisher | Brain, Behavior, and Immunity | spa |
| dc.rights.accessrights | info:eu-repo/semantics/embargoedAccess | spa |
| dc.rights.local | Acceso restringido | spa |
| dc.source | reponame:Expeditio Repositorio Institucional UJTL | spa |
| dc.source | instname:Universidad de Bogotá Jorge Tadeo Lozano | spa |
| dc.subject | COVID-19 | spa |
| dc.subject.keyword | CNS | spa |
| dc.subject.keyword | Neurologic | spa |
| dc.subject.keyword | Leukoencephalopathy | spa |
| dc.subject.keyword | Leukoaraiosis | spa |
| dc.subject.keyword | Microangiopathy | spa |
| dc.subject.keyword | COVID-19 | spa |
| dc.subject.keyword | SARS-Cov-2 | spa |
| dc.subject.keyword | Infection | spa |
| dc.subject.lemb | Síndrome respiratorio agudo grave | spa |
| dc.subject.lemb | COVID-19 | spa |
| dc.subject.lemb | SARS-CoV-2 | spa |
| dc.subject.lemb | Coronavirus | spa |
| dc.title | Brain abnormalities in COVID-19 acute/subacute phase: A rapid systematic review | spa |
| dc.type.coar | http://purl.org/coar/resource_type/c_6501 | spa |
| dc.type.hasversion | info:eu-repo/semantics/acceptedVersion | spa |
| dc.type.local | Artículo | spa |
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