Hematological features of persons with COVID-19

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dc.creatorLi, Qiubai
dc.creatorCao, Yulin
dc.creatorChen, Lei
dc.creatorWu, Di
dc.creatorYu, Jianming
dc.creatorWang, Hongxiang
dc.creatorHe, Wenjuan
dc.creatorChen, Li
dc.creatorDong, Fang
dc.creatorChen, Weiqun
dc.creatorChen, Wenlan
dc.creatorLi, Lei
dc.creatorRan, Qijie
dc.creatorLiu, Qiaomei
dc.creatorRen, Wenxiang
dc.creatorGao, Fei
dc.creatorChen, Zhichao
dc.creatorGale, Robert Peter
dc.creatorHu, Yu
dc.date.accessioned2020-07-17T14:33:37Z
dc.date.available2020-07-17T14:33:37Z
dc.date.created2020-06-11
dc.description.abstractenglishWe studied admission and dynamic demographic, hematological and biochemical co-variates in 1449 hospitalized subjects with coronavirus infectious disease-2019 (COVID-19) in five hospitals in Wuhan, Hubei province, China. We identified two admission co-variates: age (Odds Ratio [OR] = 1.18, 95% Confidence Interval [CI] [1.02, 1.36]; P = 0.026) and baseline D-dimer (OR = 3.18 [1.48, 6.82]; P = 0.003) correlated with an increased risk of death in persons with COVID-19. We also found dynamic changes in four co-variates, Δ fibrinogen (OR = 6.45 [1.31, 31.69]; P = 0.022), Δ platelets (OR = 0.95 [0.90–0.99]; P = 0.029), Δ C-reactive protein (CRP) (OR = 1.09 [1.01, 1.18]; P = 0.037), and Δ lactate dehydrogenase (LDH) (OR = 1.03 [1.01, 1.06]; P = 0.007) correlated with an increased risk of death. The potential risk factors of old age, high baseline D-dimer, and dynamic co-variates of fibrinogen, platelets, CRP, and LDH could help clinicians to identify and treat subjects with poor prognosis.spa
dc.format.extent10 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1038/s41375-020-0910-1spa
dc.identifier.issn1476-5551 (online)spa
dc.identifier.otherhttps://www.nature.com/articles/s41375-020-0910-1spa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/10722
dc.publisherLeukemiaeng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectHematologicalspa
dc.subjecthospitals in Wuhanspa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titleHematological features of persons with COVID-19spa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

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