Expansion of myeloid-derived suppressor cells in patients with severe coronavirus disease (COVID-19)

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dc.creatorAgrati, Chiara
dc.creatorSacchi, Alessandra
dc.creatorBordoni, Veronica
dc.creatorCimini, Eleonora
dc.creatorNotari, Stefania
dc.creatorGrassi, Germana
dc.creatorCasetti, Rita
dc.creatorTartaglia, Eleonora
dc.creatorLalle, Eleonora
dc.creatorD’Abramo, Alessandra
dc.creatorCastilletti, Concetta
dc.creatorMarchioni, Luisa
dc.creatorShi, Yufang
dc.creatorMariano, Andrea
dc.creatorSong, Jin-Wen
dc.creatorZhang, Ji-Yuan
dc.creatorWang, Fu-Sheng
dc.creatorZhang, Chao
dc.creatorFimia, Gian Maria
dc.creatorCapobianchi, Maria R.
dc.creatorPiacentini, Mauro
dc.creatorAntinori, Andrea
dc.creatorNicastri, Emanuele
dc.creatorMaeurer, Markus
dc.creatorZumla, Alimuddin
dc.creatorIppolito, Giuseppe
dc.date.accessioned2020-09-02T13:48:40Z
dc.date.available2020-09-02T13:48:40Z
dc.date.created2020-06-08
dc.description.abstractenglishSARS-CoV-2 is associated with a 3.4% mortality rate in patients with severe disease. The pathogenesis of severe cases remains unknown. We performed an in-depth prospective analysis of immune and inflammation markers in two patients with severe COVID-19 disease from presentation to convalescence. Peripheral blood from 18 SARS-CoV-2-infected patients, 9 with severe and 9 with mild COVID-19 disease, was obtained at admission and analyzed for T-cell activation profile, myeloid-derived suppressor cells (MDSCs) and cytokine profiles. MDSC functionality was tested in vitro. In four severe and in four mild patients, a longitudinal analysis was performed daily from the day of admission to the early convalescent phase. Early after admission severe patients showed neutrophilia, lymphopenia, increase in effector T cells, a persisting higher expression of CD95 on T cells, higher serum concentration of IL-6 and TGF-β, and a cytotoxic profile of NK and T cells compared with mild patients, suggesting a highly engaged immune response. Massive expansion of MDSCs was observed, up to 90% of total circulating mononuclear cells in patients with severe disease, and up to 25% in the patients with mild disease; the frequency decreasing with recovery. MDSCs suppressed T-cell functions, dampening excessive immune response. MDSCs decline at convalescent phase was associated to a reduction in TGF-β and to an increase of inflammatory cytokines in plasma samples. Substantial expansion of suppressor cells is seen in patients with severe COVID-19. Further studies are required to define their roles in reducing the excessive activation/inflammation, protection, influencing disease progression, potential to serve as biomarkers of disease severity, and new targets for immune and host-directed therapeutic approaches.spa
dc.format.extent12 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1038/s41418-020-0572-6spa
dc.identifier.issn1476-5403spa
dc.identifier.otherhttps://www.nature.com/articles/s41418-020-0572-6spa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/12578
dc.language.isoengspa
dc.publisherCell Death & Differentiationspa
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccessspa
dc.rights.localAcceso restringidospa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectmyeloid-derived suppressor cellsspa
dc.subjectsevere coronavirus diseasespa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titleExpansion of myeloid-derived suppressor cells in patients with severe coronavirus disease (COVID-19)spa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

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