Precision Medicine in Oncology

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dc.creatorRe, Angela
dc.creatorNardella, Caterina
dc.creatorQuattrone, Alessandro
dc.creatorLunardi, Andrea
dc.date.accessioned2020-10-06T04:01:36Z
dc.date.available2020-10-06T04:01:36Z
dc.date.created2019-01-19
dc.description.abstractenglishThe emerging precision medicine approach aims to tailor disease prevention and treatment to each patient on the basis of individual variability, environmental factors and lifestyle. Fundamental achievements in the last few decades have converged to offer nowadays the compelling opportunity to move towards this innovative approach: i) unprecedented improvements in disease modeling in silico, in vitro and in vivo; ii) acquisition of a wide range of biomedical information combined with the development of computational toolsets for flexible and integrative analyses of multi-assay datasets. Our deeper understanding of oncogenic mechanisms has finally begun to have a crucial impact on clinical decisions at several steps, from cancer prevention and diagnosis to therapeutic intervention. However, precision oncology still encounters several unresolved hurdles including tumour heterogeneity and recurrence as well as unexplained drug resistance and lack of effective ways to monitor response to therapeutic treatments. Notably, limitations in biomedical research regulation and governance represent additional debatable issues that need careful consideration.spa
dc.format.extent163 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doi10.3389/978-2-88945-705-2
dc.identifier.isbn978-2-88945-705-2
dc.identifier.issn1664-8714
dc.identifier.otherhttps://www.frontiersin.org/research-topics/5536/precision-medicine-in-oncology
dc.identifier.urihttps://hdl.handle.net/20.500.12010/14230
dc.language.isoengspa
dc.publisherFrontiers Media SAspa
dc.relation.referencesRe, A., Nardella, C., Quattrone, A., Lunardi, A., eds. (2019). Precision Medicine in Oncology. Lausanne: Frontiers Media. doi: 10.3389/978-2-88945-705-2
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonshttps://creativecommons.org/licenses/by/4.0/
dc.rights.localAbierto (Texto Completo)spa
dc.subjectOncologyspa
dc.subjectNoncoding RNAspa
dc.subjectAberrationspa
dc.subjectPathologyspa
dc.subjectIn vivo preclinical platformspa
dc.subject.keywordOncologyspa
dc.subject.keywordSynthetic biologyspa
dc.subject.lembPrecision medicinespa
dc.subject.lembComputational biologyspa
dc.titlePrecision Medicine in Oncologyspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2f33spa
dc.type.localLibrospa

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