Induction of Central Nervous System Disease by the Adaptive Immune Response

Weissert, Robert; Brilot, Fabienne

doi:10.3389/978-2-88945-347-4

Induction of Central Nervous System Disease by the Adaptive Immune Response

dc.creator	Weissert, Robert
dc.creator	Brilot, Fabienne
dc.date.accessioned	2020-10-22T20:17:39Z
dc.date.available	2020-10-22T20:17:39Z
dc.date.created	2017
dc.description.abstractenglish	Over the last years it has become evident that many neurological diseases of the central nervous system (CNS) are induced by a specific adaptive immune response directed against molecules expressed on CNS-resident cells. Well-recognized examples are anti-N-Methyl-D-Aspartate Receptor (NMDAR) encephalitis which is characterized by the presence of antibodies against neuron-expressed NMDAR, or neuromyelitis optica (NMO), induced by antibodies to astrocyte-expressed aquaporin-4. Many more examples exist, and antibodies, and T or/and B cells have increasingly been associated with CNS disease. Often the symptoms of these diseases have not been typically reported to have an immune aetiology. Beside classical neurological symptoms like ataxia, vision disturbance, and motor or sensory symptoms, these can include cognitive disturbances, behavioral abnormalities, or/and epileptic seizures. Although much has been learned regarding the pathophysiology of prototypic examples of these disorders, there are still major gaps in our understanding of their biology. This may be due to the fact that they are rare diseases, and their therapies are still very limited. This research topic includes contributions addressing the analysis of the adaptive immune response driving disease including target antigens, molecular epitope mapping, and factors involved in the disease pathogenesis such as complement activation cascades, genetic and genomic regulation, as well as environmental triggers. Diagnostic criteria and methods, and treatment are also discussed. The overall aim of the volume is to review progress in our pathophysiological understanding of immune-mediated CNS disorders in order to advance diagnostic and therapeutic approaches, and ultimately improve outcomes for patients.	spa
dc.format.extent	143 páginas	spa
dc.format.mimetype	application/pdf	spa
dc.identifier.doi	10.3389/978-2-88945-347-4
dc.identifier.isbn	978-2-889-45347-4
dc.identifier.issn	1664-8714
dc.identifier.other	https://www.frontiersin.org/research-topics/4667/induction-of-central-nervous-system-disease-by-the-adaptive-immune-response#nogo
dc.identifier.uri	https://hdl.handle.net/20.500.12010/14809
dc.language.iso	eng	spa
dc.publisher	Frontiers Media SA	spa
dc.rights.accessrights	info:eu-repo/semantics/openAccess	spa
dc.rights.creativecommons	https://creativecommons.org/licenses/by/4.0/legalcode
dc.rights.local	Abierto (Texto Completo)	spa
dc.subject	Medicina	spa
dc.subject.lemb	Esclerosis múltiple	spa
dc.subject.lemb	Trastorno del espectro óptico neuromielitis	spa
dc.subject.lemb	Encefalitis autoinmunitaria	spa
dc.title	Induction of Central Nervous System Disease by the Adaptive Immune Response	spa
dc.type.coar	http://purl.org/coar/resource_type/c_2f33	spa
dc.type.local	Libro	spa

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