Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States

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dc.creatorKujawski, Stephanie A.
dc.creatorWong, Karen K.
dc.creatorCollins, Jennifer P.
dc.creatorEpstein, Lauren
dc.creatorKillerby, Marie E.
dc.creatorMidgley, Claire M.
dc.creatorAbedi, Glen R.
dc.creatorAhmed, N. Seema
dc.creatorAlmendares, Olivia
dc.creatorAlvarez, Francisco N.
dc.creatorAnderson, Kayla N.
dc.creatorBalter, Sharon
dc.creatorBarry, Vaughn
dc.creatorBartlett, Karri
dc.creatorBeer, Karlyn
dc.creatorBen-Aderet, Michael A.
dc.creatorBenowitz, Isaac
dc.creatorBiggs, Holly M.
dc.creatorBinder, Alison M.
dc.creatorBlack, Stephanie R.
dc.creatorBonin, Brandon
dc.creatorBozio, Catherine H.
dc.creatorBrown, Catherine M.
dc.creatorBruce, Hollianne
dc.creatorBryant-Genevier, Jonathan
dc.creatorBudd, Alicia
dc.creatorBuell, Diane
dc.creatorBystritsky, Rachel
dc.creatorCates, Jordan
dc.creatorCharles, E. Matt
dc.creatorChatham-Stephens, Kevin
dc.creatorChea, Nora
dc.creatorChiou, Howard
dc.creatorChristiansen, Demian
dc.creatorChu, Victoria
dc.creatorCody, Sara
dc.creatorCohen, Max
dc.creatorConners, Erin E.
dc.creatorCurns, Aaron T.
dc.creatorDasari, Vishal
dc.creatorDawson, Patrick
dc.creatorDeSalvo, Traci
dc.creatorDiaz, George
dc.creatorDonahue, Matthew
dc.creatorDonovan, Suzanne
dc.creatorDuca, Lindsey M.
dc.creatorErickson, Keith
dc.creatorEsona, Mathew D.
dc.creatorEvans, Suzanne
dc.creatorFalk, Jeremy
dc.creatorFeldstein, Leora R.
dc.creatorFenstersheib, Martin
dc.creatorFischer, Marc
dc.creatorFisher, Rebecca
dc.creatorFoo, Chelsea
dc.creatorFricchione, Marielle J.
dc.creatorFriedman, Oren
dc.creatorFry, Alicia
dc.creatorGalang, Romeo R.
dc.creatorGarcia, Melissa M.
dc.creatorGerber, Susan I.
dc.creatorGerrard, Graham
dc.creatorGhinai, Isaac
dc.creatorGounder, Prabhu
dc.creatorGrein, Jonathan
dc.creatorGrigg, Cheri
dc.creatorGunzenhauser, Jeffrey D.
dc.creatorGutkin, Gary I.
dc.creatorHaddix, Meredith
dc.creatorHall, Aron J.
dc.creatorHan, George S.
dc.creatorHarcourt, Jennifer
dc.creatorHarriman, Kathleen
dc.creatorHaupt, Thomas
dc.creatorHaynes, Amber K.
dc.creatorHolshue, Michelle
dc.creatorHoover, Cora
dc.creatorHunter, Jennifer C.
dc.creatorJacobs, Max W.
dc.creatorJarashow, Claire
dc.creatorJoshi, Kiran
dc.creatorKamali, Talar
dc.creatorKamili, Shifaq
dc.creatorKim, Lindsay
dc.creatorKim, Moon
dc.creatorKing, Jan
dc.creatorKirking, Hannah L.
dc.creatorKita-Yarbro, Amanda
dc.creatorKlos, Rachel
dc.creatorKobayashi, Miwako
dc.creatorKocharian, Anna
dc.creatorKomatsu, Kenneth K.
dc.creatorKoppaka, Ram
dc.creatorLayden, Jennifer E.
dc.creatorLi, Yan
dc.creatorLindquist, Scott
dc.creatorLindstrom, Stephen
dc.creatorLink-Gelles, Ruth
dc.creatorLively, Joana
dc.creatorLivingston, Michelle
dc.creatorLo, Kelly
dc.creatorLo, Jennifer
dc.creatorLu, Xiaoyan
dc.creatorLynch, Brian
dc.creatorMadoff, Larry
dc.creatorMalapati, Lakshmi
dc.creatorMarks, Gregory
dc.creatorMarlow, Marielathisen, Glenn E.
dc.creatorMcClung, Nancy
dc.creatorMcGovern, Olivia
dc.creatorMcPherson, Tristan D.
dc.creatorMehta, Mitali
dc.creatorMeier, Audrey
dc.creatorMello, Lynn
dc.creatorMoon, Sung sil
dc.creatorMorgan, Margie
dc.creatorMoro, Ruth N.
dc.creatorMurray, Janna’
dc.creatorMurthy, Rekha
dc.creatorNovosad, Shannon
dc.creatorOliver, Sara E.
dc.creatorO’Shea, Jennifer
dc.creatorPacilli, Massimo
dc.creatorPaden, Clinton R.
dc.creatorPallansch, Mark A.
dc.creatorPatel, Manisha
dc.creatorPatel, Sajan
dc.creatorPedraza, Isabel
dc.creatorPillai, Satish K.
dc.creatorPindyck, Talia
dc.creatorPray, Ian
dc.creatorQueen, Krista
dc.creatorQuick, Nichole
dc.creatorReese, Heather
dc.creatorReporter, Roshan
dc.creatorRha, Brian
dc.creatorRhodes, Heather
dc.creatorRobinson, Susan
dc.creatorRobinson, Philip
dc.creatorRolfes, Melissa A.
dc.creatorRouth, Janell A.
dc.creatorRubin, Rachel
dc.creatorRudman, Sarah L.
dc.creatorSakthivel, Senthilkumar K.
dc.creatorScott, Sarah
dc.creatorShepherd, Christopher
dc.creatorShetty, Varun
dc.creatorSmith, Ethan A.
dc.creatorSmith, Shanon
dc.creatorStierman, Bryan
dc.creatorStoecker, William
dc.creatorSunenshine, Rebecca
dc.creatorSy-Santos, Regina
dc.creatorTamin, Azaibi
dc.creatorTao, Ying
dc.creatorTerashita, Dawn
dc.creatorThornburg, Natalie J.
dc.creatorTong, Suxiang
dc.creatorTraub, Elizabeth
dc.creatorTural, Ahmet
dc.creatorUehara, Anna
dc.creatorUyeki, Timothy M.
dc.creatorVahey, Grace
dc.creatorVerani, Jennifer R.
dc.creatorVillarino, Elsa
dc.creatorWallace, Megan
dc.creatorWang, Lijuan
dc.creatorWatson, John T.
dc.creatorWestercamp, Matthew
dc.creatorWhitaker, Brett
dc.creatorWilkerson, Sarah
dc.creatorWoodruff, Rebecca C.
dc.creatorWortham, Jonathan M.
dc.creatorWu, Tiffany
dc.creatorXie, Amy
dc.creatorYousaf, Anna
dc.creatorZahn, Matthew
dc.creatorZhang, Jing
dc.date.accessioned2020-07-17T22:02:08Z
dc.date.available2020-07-17T22:02:08Z
dc.date.created2020-04-23
dc.description.abstractenglishData on the detailed clinical progression of COVID-19 in conjunction with epidemiological and virological characteristics are limited. In this case series, we describe the first 12 US patients confirmed to have COVID-19 from 20 January to 5 February 2020, including 4 patients described previously1,2,3. Respiratory, stool, serum and urine specimens were submitted for SARS-CoV-2 real-time reverse-transcription polymerase chain reaction (rRT-PCR) testing, viral culture and whole genome sequencing. Median age was 53 years (range: 21–68); 8 patients were male. Common symptoms at illness onset were cough (n = 8) and fever (n = 7). Patients had mild to moderately severe illness; seven were hospitalized and demonstrated clinical or laboratory signs of worsening during the second week of illness. No patients required mechanical ventilation and all recovered. All had SARS-CoV-2 RNA detected in respiratory specimens, typically for 2–3 weeks after illness onset. Lowest real-time PCR with reverse transcription cycle threshold values in the upper respiratory tract were often detected in the first week and SARS-CoV-2 was cultured from early respiratory specimens. These data provide insight into the natural history of SARS-CoV-2. Although infectiousness is unclear, highest viral RNA levels were identified in the first week of illness. Clinicians should anticipate that some patients may worsen in the second week of illness.spa
dc.format.extent23 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1038/s41591-020-0877-5spa
dc.identifier.issn1546-170Xspa
dc.identifier.otherhttps://www.nature.com/articles/s41591-020-0877-5spa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/10812
dc.publisherScience Directeng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCOVID-19 -- Estados Unidosspa
dc.subject.keywordClinical characteristicsspa
dc.subject.keywordVirologic characteristicsspa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titleClinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United Statesspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

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