Validation of a digital pathology system including remote review during the COVID-19 pandemic

Vista sencilla de ítem
dc.creatorHanna, Matthew G.
dc.creatorReuter, Victor E.
dc.creatorArdon, Orly
dc.creatorKim, David
dc.creatorSirintrapun, Sahussapont Joseph
dc.creatorSchüffler, Peter J.
dc.creatorBusam, Klaus J.
dc.creatorSauter, Jennifer L.
dc.creatorBrogi, Edi
dc.creatorTan, Lee K.
dc.creatorXu, Bin
dc.creatorBale, Tejus
dc.creatorAgaram, Narasimhan P.
dc.creatorTang, Laura H.
dc.creatorEllenson, Lora H.
dc.creatorPhilip, John
dc.creatorCorsale, Lorraine
dc.creatorStamelos, Evangelos
dc.creatorFriedlander, Maria A.
dc.creatorNtiamoah, Peter
dc.creatorLabasin, Marc
dc.creatorEngland, Christine
dc.creatorKlimstra, David S.
dc.creatorHameed, Meera
dc.date.accessioned2020-07-16T16:51:07Z
dc.date.available2020-07-16T16:51:07Z
dc.date.created2020-06-22
dc.description.abstractenglishRemote digital pathology allows healthcare systems to maintain pathology operations during public health emergencies. Existing Clinical Laboratory Improvement Amendments regulations require pathologists to electronically verify patient reports from a certified facility. During the 2019 pandemic of COVID-19 disease, caused by the SAR-CoV-2 virus, this requirement potentially exposes pathologists, their colleagues, and household members to the risk of becoming infected. Relaxation of government enforcement of this regulation allows pathologists to review and report pathology specimens from a remote, non-CLIA certified facility. The availability of digital pathology systems can facilitate remote microscopic diagnosis, although formal comprehensive (case-based) validation of remote digital diagnosis has not been reported. All glass slides representing routine clinical signout workload in surgical pathology subspecialties at Memorial Sloan Kettering Cancer Center were scanned on an Aperio GT450 at ×40 equivalent resolution (0.26 µm/pixel). Twelve pathologists from nine surgical pathology subspecialties remotely reviewed and reported complete pathology cases using a digital pathology system from a non-CLIA certified facility through a secure connection. Whole slide images were integrated to and launched within the laboratory information system to a custom vendor-agnostic, whole slide image viewer. Remote signouts utilized consumer-grade computers and monitors (monitor size, 13.3–42 in.; resolution, 1280 × 800–3840 × 2160 pixels) connecting to an institution clinical workstation via secure virtual private network. Pathologists subsequently reviewed all corresponding glass slides using a light microscope within the CLIA-certified department. Intraobserver concordance metrics included reporting elements of top-line diagnosis, margin status, lymphovascular and/or perineural invasion, pathology stage, and ancillary testing. The median whole slide image file size was 1.3 GB; scan time/slide averaged 90 s; and scanned tissue area averaged 612 mm2. Signout sessions included a total of 108 cases, comprised of 254 individual parts and 1196 slides. Major diagnostic equivalency was 100% between digital and glass slide diagnoses; and overall concordance was 98.8% (251/254). This study reports validation of primary diagnostic review and reporting of complete pathology cases from a remote site during a public health emergency. Our experience shows high (100%) intraobserver digital to glass slide major diagnostic concordance when reporting from a remote site. This randomized, prospective study successfully validated remote use of a digital pathology system including operational feasibility supporting remote review and reporting of pathology specimens, and evaluation of remote access performance and usability for remote signout.spa
dc.format.extent13 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1038/s41379-020-0601-5spa
dc.identifier.issn1530-0285 (online)spa
dc.identifier.otherhttps://www.nature.com/articles/s41379-020-0601-5spa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/10671
dc.publisherModern Pathologyeng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectpathology systemspa
dc.subjectremote microscopic diagnosisspa
dc.subjectpathology subspecialtiesspa
dc.subjectCLIAspa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titleValidation of a digital pathology system including remote review during the COVID-19 pandemicspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

Archivos

Bloque original

Mostrando 1 - 1 de 1
Miniatura
Nombre:
Validation of a digital pathology system including remote review during the COVID-19 pandemic.pdf
Tamaño:
1.2 MB
Formato:
Adobe Portable Document Format
Descripción:
Documento Reservado
Descargar

Bloque de licencias

Mostrando 1 - 1 de 1
Miniatura
Nombre:
license.txt
Tamaño:
2.87 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

Documentos científicos relacionados a la COVID-19

Carrera 4 # 22-61 Teléfono: (+57) 601 242 7030 - 018000111022 Fax: (+57) 601 561 2107 Bogotá D.C., Colombia

Fundación Universitaria de Bogotá Jorge Tadeo Lozano | Vigilada Mineducación

Institución de educación superior privada, de utilidad común, sin ánimo de lucro y su carácter académico es el de Universidad

Reconocimiento personería jurídica: Resolución 2613 del 14 de agosto de 1959 Minjusticia.

Institución de Educación Superior sujeta a inspección y vigilancia por el Ministerio de Educación Nacional.

Software DSpace copyright © 2002-2026 LYRASIS