Single cell transcriptome revealed SARS-CoV-2 entry genes enriched in colon tissues and associated with coronavirus infection and cytokine production

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dc.creatorChen, Haoyan
dc.creatorZou, Tian-Hui
dc.creatorXuan, Baoqin
dc.creatorYan, Yuqing
dc.creatorYan, Tingting
dc.creatorShen, Chaoqin
dc.creatorZhao, Gang
dc.creatorChen, Ying-Xuan
dc.creatorXiao, Xiao
dc.creatorHong, Jie
dc.creatorFang, Jing-Yuan
dc.date.accessioned2020-09-04T13:16:01Z
dc.date.available2020-09-04T13:16:01Z
dc.date.created2020-07-08
dc.description.abstractenglishDear Editor, The novel COVID-19 coronavirus (SARS-CoV-2) endangers thousands of lives. Recently, nearly 10% COVID-19 patients with symptoms of the digestive tract were subsequently diagnosed in newly discovered SARS-CoV-2 infected cases,1 which indicates that SARS-CoV-2 may infect people via digestive systems. The expression profile of angiotensin-converting enzyme homolog 2 (ACE2) has been analyzed in gastrointestinal tract using external datasets. Unfortunately, most data of these datasets are not from Asian adults and the expression of other SARS-CoV-2 entry genes have not been detected in human gastrointestinal tract. Therefore, to provide more implications of viral transmission in clinical diagnosis and treatment, it is urgent to explore the expression of SARS-CoV-2 entry genes in the gastrointestinal tract of Asian people. Here, we used single-cell RNA sequencing profiled ~27,800 cells of intestinal tissues from six patients with basic intestinal disease of Renji hospital.spa
dc.format.extent3 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1038/s41392-020-00237-0spa
dc.identifier.issn2059-3635spa
dc.identifier.otherhttps://www.nature.com/articles/s41392-020-00237-0spa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/12689
dc.language.isospaspa
dc.publishersignal transduction and targeted therapyspa
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccessspa
dc.rights.localAcceso restringidospa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectSingle cell transcriptomespa
dc.subjectcolon tissuesspa
dc.subjectcoronavirus infectionspa
dc.subjectcytokine productionspa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titleSingle cell transcriptome revealed SARS-CoV-2 entry genes enriched in colon tissues and associated with coronavirus infection and cytokine productionspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

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