COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis

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dc.creatorChua, Robert Lorenz
dc.creatorLukassen, Soeren
dc.creatorTrump, Saskia
dc.creatorHennig, Bianca P.
dc.creatorWendisch, Daniel
dc.creatorPott, Fabian
dc.creatorDebnath, Olivia
dc.creatorThürmann, Loreen
dc.creatorKurth, Florian
dc.creatorVölker, Maria Theresa
dc.creatorKazmierski, Julia
dc.creatorTimmermann, Bernd
dc.creatorTimmermann, Bernd
dc.creatorTwardziok, Sven
dc.creatorSchneider, Stefan
dc.creatorMachleidt, Felix
dc.creatorMüller-Redetzky, Holger
dc.creatorMaier, Melanie
dc.creatorKrannich, Alexander
dc.creatorSchmidt, Sein
dc.creatorBalzer, Felix
dc.creatorLiebig, Johannes
dc.creatorLoske, Jennifer
dc.creatorSuttorp, Norbert
dc.creatorEils, Jürgen
dc.creatorIshaque, Naveed
dc.creatorLiebert, Uwe Gerd
dc.creatorvon Kalle, Christof
dc.creatorHocke, Andreas
dc.creatorWitzenrath, Martin
dc.creatorGoffinet, Christine
dc.creatorDrosten, Christian
dc.creatorLaudi, Sven
dc.creatorLehmann, Irina
dc.creatorConrad, Christian
dc.creatorSander, Leif Erik
dc.creatorEils, Roland
dc.date.accessioned2020-07-17T22:40:50Z
dc.date.available2020-07-17T22:40:50Z
dc.date.created2020-06-26
dc.description.abstractenglishTo investigate the immune response and mechanisms associated with severe coronavirus disease 2019 (COVID-19), we performed single-cell RNA sequencing on nasopharyngeal and bronchial samples from 19 clinically well-characterized patients with moderate or critical disease and from five healthy controls. We identified airway epithelial cell types and states vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In patients with COVID-19, epithelial cells showed an average three-fold increase in expression of the SARS-CoV-2 entry receptor ACE2, which correlated with interferon signals by immune cells. Compared to moderate cases, critical cases exhibited stronger interactions between epithelial and immune cells, as indicated by ligand–receptor expression profiles, and activated immune cells, including inflammatory macrophages expressing CCL2, CCL3, CCL20, CXCL1, CXCL3, CXCL10, IL8, IL1B and TNF. The transcriptional differences in critical cases compared to moderate cases likely contribute to clinical observations of heightened inflammatory tissue damage, lung injury and respiratory failure. Our data suggest that pharmacologic inhibition of the CCR1 and/or CCR5 pathways might suppress immune hyperactivation in critical COVID-19.spa
dc.format.extent25 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1038/s41587-020-0602-4spa
dc.identifier.issn1546-1696spa
dc.identifier.otherhttps://www.nature.com/articles/s41587-020-0602-4spa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/10816
dc.publisherScience Directeng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectInteracción de célulasspa
dc.subject.keywordCell interactionsspa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titleCOVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysisspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

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