Comparative studies between HTLV-1 and HTLV-2 function and pathobiology
| dc.creator | Bertazzoni, Umberto | |
| dc.creator | Bex, Françoise | |
| dc.date.accessioned | 2020-10-13T16:46:24Z | |
| dc.date.available | 2020-10-13T16:46:24Z | |
| dc.date.created | 2015-11-16 | |
| dc.description.abstractenglish | Human T-cell leukemia viruses type 1 and 2 (HTLV-1 and HTLV-2) share a common genetic organization, expression strategy and ability to infect and immortalize T-cells in vitro; however, HTLV-1 and HTLV-2 are strikingly different in terms of clinical impact. HTLV-1 is recognized as the aetiological agent of adult T-cell leukemia/lymphoma (ATLL), and HTLV-associated myeolopathy/tropical spastic paraparesis (HAM/TSP), in contrast, HTLV-2 does not cause hematologic disorders and is only sporadically associated with cases of subacute myelopathy. HTLV-1 and HTLV-2 also exhibit distinct cellular tropisms in vivo: HTLV-1 is mainly found in CD4+T lymphocytes, whereas CD8+T-cells are the preferred target for HTLV-2. The articles contributed in this Research Topic are covering all the different aspects that characterize HTLV-1 and HTLV-2, by highlighting differences in their biology that might provide clues to their distinct pathogenic properties. | spa |
| dc.format.extent | 95 páginas | spa |
| dc.format.mimetype | application/pdf | spa |
| dc.identifier.doi | 10.3389/978-2-88919-498-8 | |
| dc.identifier.isbn | 978-2-889-19498-8 | |
| dc.identifier.issn | 1664-8714 | |
| dc.identifier.other | https://www.frontiersin.org/research-topics/1265/comparative-studies-between-htlv-1-and-htlv-2-function-and-pathobiology | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12010/14390 | |
| dc.language.iso | eng | spa |
| dc.publisher | Frontiers Media SA | spa |
| dc.relation.references | Bertazzoni U (2015) Editorial to the Research Topic “Comparative studies between HTLV-1 and HTLV-2 function and pathobiology”. Front. Microbiol. 5:792. doi: 10.3389/fmicb.2014.00792 | spa |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
| dc.rights.creativecommons | https://creativecommons.org/licenses/by/4.0/legalcode | |
| dc.rights.local | Abierto (Texto Completo) | spa |
| dc.subject | Ciencia | spa |
| dc.subject.lemb | Microbiología | spa |
| dc.subject.lemb | Proteínas | spa |
| dc.subject.lemb | Función HTLV-1 y HTLV-2 | spa |
| dc.title | Comparative studies between HTLV-1 and HTLV-2 function and pathobiology | spa |
| dc.type.coar | http://purl.org/coar/resource_type/c_2f33 | spa |
| dc.type.local | Libro | spa |
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