Numerical evaluation of spray position for improved nasal drug delivery
| dc.creator | Basu, Saikat | |
| dc.creator | Holbrook, Landon T. | |
| dc.creator | Kudlaty, Kathryn | |
| dc.creator | Fasanmade, Olulade | |
| dc.creator | Wu, Jihong | |
| dc.creator | Burke, Alyssa | |
| dc.creator | Langworthy, Benjamin W. | |
| dc.creator | Farzal, Zainab | |
| dc.creator | Mamdani, Mohammed | |
| dc.creator | Bennett, William D. | |
| dc.creator | Fine, Jason P. | |
| dc.creator | Senior, Brent A. | |
| dc.creator | Zanation, Adam M. | |
| dc.creator | Ebert, Charles S. | |
| dc.creator | Kimple, Adam J. | |
| dc.creator | Thorp, Brian D. | |
| dc.creator | Frank-Ito, Dennis O. | |
| dc.creator | Garcia, Guilherme J.M. | |
| dc.creator | Kimbell, Julia S. | |
| dc.date.accessioned | 2020-07-22T00:07:34Z | |
| dc.date.available | 2020-07-22T00:07:34Z | |
| dc.date.created | 2020-06-29 | |
| dc.description.abstractenglish | Topical intra-nasal sprays are amongst the most commonly prescribed therapeutic options for sinonasal diseases in humans. However, inconsistency and ambiguity in instructions show a lack of definitive knowledge on best spray use techniques. In this study, we have identified a new usage strategy for nasal sprays available over-the-counter, that registers an average 8-fold improvement in topical delivery of drugs at diseased sites, when compared to prevalent spray techniques. The protocol involves re-orienting the spray axis to harness inertial motion of particulates and has been developed using computational fluid dynamics simulations of respiratory airflow and droplet transport in medical imaging-based digital models. Simulated dose in representative models is validated through in vitro spray measurements in 3D-printed anatomic replicas using the gamma scintigraphy technique. This work breaks new ground in proposing an alternative user-friendly strategy that can significantly enhance topical delivery inside human nose. While these findings can eventually translate into personalized spray usage instructions and hence merit a change in nasal standard-of-care, this study also demonstrates how relatively simple engineering analysis tools can revolutionize everyday healthcare. Finally, with respiratory mucosa as the initial coronavirus infection site, our findings are relevant to intra-nasal vaccines that are in-development, to mitigate the COVID-19 pandemic. | spa |
| dc.format.extent | 18 páginas | spa |
| dc.format.mimetype | application/pdf | spa |
| dc.identifier.doi | https://doi.org/10.1038/s41598-020-66716-0 | spa |
| dc.identifier.issn | 2045-2322 | spa |
| dc.identifier.other | https://www.nature.com/articles/s41598-020-66716-0 | spa |
| dc.identifier.uri | https://hdl.handle.net/20.500.12010/10917 | |
| dc.publisher | Science Direct | eng |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
| dc.source | reponame:Expeditio Repositorio Institucional UJTL | spa |
| dc.source | instname:Universidad de Bogotá Jorge Tadeo Lozano | spa |
| dc.subject | Administración nasal de fármacos | spa |
| dc.subject.keyword | Nasal drug delivery | spa |
| dc.subject.lemb | Síndrome respiratorio agudo grave | spa |
| dc.subject.lemb | COVID-19 | spa |
| dc.subject.lemb | SARS-CoV-2 | spa |
| dc.subject.lemb | Coronavirus | spa |
| dc.title | Numerical evaluation of spray position for improved nasal drug delivery | spa |
| dc.type.hasversion | info:eu-repo/semantics/acceptedVersion | spa |
| dc.type.local | Artículo | spa |
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