Applicability of time fractional derivative models for simulating the dynamics and mitigation scenarios of COVID-19

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dc.creatorZhang, Yong
dc.creatorYu, Xiangnan
dc.creatorSun, Hong Guang
dc.creatorTick, Geoffrey R.
dc.creatorWei, Wei
dc.creatorJin, Bin
dc.date.accessioned2020-07-27T21:17:51Z
dc.date.available2020-07-27T21:17:51Z
dc.date.created2020-09
dc.description.abstractenglishFractional calculus provides a promising tool for modeling fractional dynamics in computational biology, and this study tests the applicability of fractional-derivative equations (FDEs) for modeling the dynamics and mitigation scenarios of the novel coronavirus for the first time. The coronavirus disease 2019 (COVID-19) pandemic radically impacts our lives, while the evolution dynamics of COVID-19 remain obscure. A time-dependent Susceptible, Exposed, Infectious, and Recovered (SEIR) model was proposed and applied to fit and then predict the time series of COVID-19 evolution observed over the last three months (up to 3/22/2020) in China. The model results revealed that 1) the transmission, infection and recovery dynamics follow the integral-order SEIR model with significant spatiotemporal variations in the recovery rate, likely due to the continuous improvement of screening techniques and public hospital systems, as well as full city lockdowns in China, and 2) the evolution of number of deaths follows the time FDE, likely due to the time memory in the death toll. The validated SEIR model was then applied to predict COVID-19 evolution in the United States, Italy, Japan, and South Korea. In addition, a time FDE model based on the random walk particle tracking scheme, analogous to a mixing-limited bimolecular reaction model, was developed to evaluate non-pharmaceutical strategies to mitigate COVID-19 spread. Preliminary tests using the FDE model showed that self-quarantine may not be as efficient as strict social distancing in slowing COVID-19 spread. Therefore, caution is needed when applying FDEs to model the coronavirus outbreak, since specific COVID-19 kinetics may not exhibit nonlocal behavior. Particularly, the spread of COVID-19 may be affected by the rapid improvement of health care systems which may remove the memory impact in COVID-19 dynamics (resulting in a short-tailed recovery curve), while the death toll and mitigation of COVID-19 can be captured by the time FDEs due to the nonlocal, memory impact in fatality and human activities.spa
dc.format.extent12 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1016/j.chaos.2020.109959spa
dc.identifier.issn0960-0779spa
dc.identifier.otherhttps://www.sciencedirect.com/science/article/pii/S0960077920303581?via%3Dihubspa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/11239
dc.publisherChaos, Solitons and Fractalseng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCálculo fraccionalspa
dc.subjectEcuación derivada fraccionalspa
dc.subject.keywordFractional calculusspa
dc.subject.keywordBiologyspa
dc.subject.keywordSEIRspa
dc.subject.keywordFractional derivative equationspa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titleApplicability of time fractional derivative models for simulating the dynamics and mitigation scenarios of COVID-19spa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

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