Suppression of a SARS-CoV-2 outbreak in the Italian municipality of Vo’

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dc.creatorLavezzo, Enrico
dc.creatorFranchin, Elisa
dc.creatorCiavarella, Constanze
dc.creatorCuomo-Dannenburg, Gina
dc.creatorBarzon, Luisa
dc.creatorDel Vecchio, Claudia
dc.creatorRossi, Lucia
dc.creatorManganelli, Riccardo
dc.creatorLoregian, Arianna
dc.creatorNavarin, Nicolò
dc.creatorAbate, Davide
dc.creatorSciro, Manuela
dc.creatorMerigliano, Stefano
dc.creatorDe Canale, Ettore
dc.creatorVanuzzo, Maria Cristina
dc.creatorBesutti, Valeria
dc.creatorSaluzzo, Francesca
dc.creatorOnelia, Francesco
dc.creatorPacenti, Monia
dc.creatorParisi, Saverio
dc.creatorCarretta, Giovanni
dc.creatorDonato, Daniele
dc.creatorFlor, Luciano
dc.creatorCocchio, Silvia
dc.creatorMasi, Giulia
dc.creatorSperduti, Alessandro
dc.creatorCattarino, Lorenzo
dc.creatorSalvador, Renato
dc.creatorNicoletti, Michele
dc.creatorCaldart, Federico
dc.creatorCastelli, Gioele
dc.creatorNieddu, Eleonora
dc.creatorLabella, Beatrice
dc.creatorFava, Ludovico
dc.creatorDrigo, Matteo
dc.creatorGaythorpe, Katy A. M.
dc.creatorBrazzale, Alessandra R.
dc.creatorToppo, Stefano
dc.creatorTrevisan, Marta
dc.creatorBaldo, Vincenzo
dc.creatorDonnelly, Christl A.
dc.creatorFerguson, Neil M.
dc.creatorDorigatti, Ilaria
dc.creatorCrisanti, Andrea
dc.date.accessioned2020-07-22T15:57:43Z
dc.date.available2020-07-22T15:57:43Z
dc.date.created2020-06-30
dc.description.abstractenglishOn 21 February 2020, a resident of the municipality of Vo’, a small town near Padua (Italy), died of pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection1. This was the first COVID-19 death detected in Italy since the detection of SARS-CoV-2 in the Chinese city of Wuhan, Hubei province2. In response, the regional authorities imposed the lockdown of the whole municipality for 14 days3. We collected information on the demography, clinical presentation, hospitalization, contact network and the presence of SARS-CoV-2 infection in nasopharyngeal swabs for 85.9% and 71.5% of the population of Vo’ at two consecutive time points. From the first survey, which was conducted around the time the town lockdown started, we found a prevalence of infection of 2.6% (95% confidence interval (CI): 2.1–3.3%). From the second survey, which was conducted at the end of the lockdown, we found a prevalence of 1.2% (95% CI: 0.8–1.8%). Notably, 42.5% (95% CI: 31.5–54.6%) of the confirmed SARS-CoV-2 infections detected across the two surveys were asymptomatic (that is, did not have symptoms at the time of swab testing and did not develop symptoms afterwards). The mean serial interval was 7.2 days (95% CI: 5.9–9.6). We found no statistically significant difference in the viral load of symptomatic versus asymptomatic infections (P = 0.62 and 0.74 for E and RdRp genes, respectively, exact Wilcoxon–Mann–Whitney test). This study sheds new light on the frequency of asymptomatic SARS-CoV-2 infection, their infectivity (as measured by the viral load) and provides new insights into its transmission dynamics and the efficacy of the implemented control measures.spa
dc.format.extent23 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1038/s41586-020-2488-1spa
dc.identifier.issn1476-4687spa
dc.identifier.otherhttps://www.nature.com/articles/s41586-020-2488-1spa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/10940
dc.publisherScience Directeng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectSARS-CoV-2 -- Italiaspa
dc.subject.keywordSARS-CoV-2 -- Italyspa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titleSuppression of a SARS-CoV-2 outbreak in the Italian municipality of Vo’spa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

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