Mechanism of inflammatory response in associated comorbidities in COVID-19

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dc.creatorLucena, Maria Costa de
dc.creatorSilva Santos, Ariane Fernandes da
dc.creatorLima, Brenda Regina de
dc.creatorAlbuquerque Borborema, Maria Eduarda de
dc.creatorAzevêdo Silvaab, Jaqueline de
dc.date.accessioned2020-07-31T20:43:35Z
dc.date.available2020-07-31T20:43:35Z
dc.date.created2020-05-09
dc.description.abstractenglishBackground and aims The outbreak of the new coronavirus, SARS-CoV-2, causes a respiratory disease and individuals with pre-existing cardiometabolic disorders display worse prognosis through the infection course. The aim of this minireview is to present epidemiological data related to metabolic comorbidities in association with the SARS-CoV-2. Methods This is a narrative mini-review with Pubmed search until April 23, 2020 using the keywords COVID-19, SARS-CoV-2, treatment of coronavirus and following terms: diabetes mellitus, obesity, arterial hypertension, ACE-inhibitors, cytokine storm, immune response and vitamin D. Results Studies indicate that obese individuals are more likely to develop infections, and that adipose tissue serves as a pathogen reservoir. In diabetic individuals higher rate of inflammatory processes is seen due to constant glucose recognition by C type lectin receptors. Hypertensive individuals, usually grouped with other conditions, are treated with drugs to reduce blood pressure mostly through ACEi and ARB, that leads to increased ACE2 expression, used by SARS-CoV-2 for human’s cell entry. Until now, the studies have shown that individuals with those conditions and affected by COVID-19 present an uncontrolled release of pro-inflammatory cytokines and an unbalanced immune response, leading to the cytokine storm phenomenon. Vitamin D is highlighted as a potential therapeutic target, because in addition to acting on the immune system, it plays an important role in the control of cardiometabolic diseases. Conclusion Currently, since there is no proven and effective antiviral therapy for SARS-CoV-2, the efforts should focus on controlling inflammatory response and reduce the risks of associated complications.spa
dc.format.extent4 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1016/j.dsx.2020.05.025spa
dc.identifier.issn1871-4021spa
dc.identifier.otherhttps://www.sciencedirect.com/science/article/pii/S1871402120301430?via%3Dihub#kwrds0010spa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/11500
dc.publisherDiabetes & Metabolic Syndrome: Clinical Research & Reviewseng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectDiabetes mellitusspa
dc.subjectObesityspa
dc.subjectHypertension arterialspa
dc.subjectVitamin Dspa
dc.subjectImmune responsespa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titleMechanism of inflammatory response in associated comorbidities in COVID-19spa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

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