Predictive factors for disease progression in hospitalized patients with coronavirus disease 2019 in Wuhan, China

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dc.creatorZhang, Jun
dc.creatorYu, Miao
dc.creatorTong, Song
dc.creatorLiu, Lu-Yu
dc.creatorTang, Liang-V.
dc.date.accessioned2020-07-28T22:25:36Z
dc.date.available2020-07-28T22:25:36Z
dc.date.created2020-04-26
dc.description.abstractenglishBackground A few studies have revealed the clinical characteristics of hospitalized patients with COVID-19. However, predictive factors for the outcomes remain unclear. Objective Attempted to determine the predictive factors for the poor outcomes of patients with COVID-19. Study design This is a single-center, retrospective study. Clinical, laboratory, and treatment data were collected and analyzed from 111 hospitalized patients with laboratory-confirmed COVID-19 in Union Hospital. The gathered data of discharged and deteriorated patients were compared. Results Among these 111 patients, 93 patients were discharged and 18 patients were deteriorated. The lymphocyte count (0.56 G/L [0.47−0.63] vs 1.30 G/L [0.95−1.65]) was lower in the deteriorated group than those in the discharged group. The numbers of pulmonary lobe involved (5.00 [5.00–5.00] vs 4.00 [2.00−5.00]), serum C‐reactive protein (CRP, 79.52 mg/L [61.25−102.98] vs 7.93 mg/L [3.14−22.50]), IL-6 (35.72 pg/mL [9.24−85.19] vs 5.09 pg/mL [3.16−9.72]), and IL-10 (5.35 pg/mL [4.48−7.84] vs 3.97 pg/mL [3.34−4.79]) concentrations in deteriorated patients were elevated compared with discharged patients. Multivariate logistic regression analysis showed that male gender (OR, 24.8 [1.8−342.1]), comorbidity (OR, 52.6 [3.6−776.4]), lymphopenia (OR, 17.3 [1.1−261.8]), and elevated CRP (OR, 96.5 [4.6−2017.6]) were the independent risk factors for the poor prognosis in COVID-19 patients. Conclusions This finding would facilitate the early identification of high-risk COVID-19 patients.spa
dc.format.extent5 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1016/j.jcv.2020.104392spa
dc.identifier.issn1386-6532spa
dc.identifier.otherhttps://www.sciencedirect.com/science/article/pii/S1386653220301347?via%3Dihubspa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/11324
dc.publisherJournal of Clinical Virologyeng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCoronavirus disease 2019spa
dc.subjectPredictive factorsspa
dc.subjectPrognosisspa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titlePredictive factors for disease progression in hospitalized patients with coronavirus disease 2019 in Wuhan, Chinaspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

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