Aberrant hyperactivation of cytotoxic T-cell as a potential determinant of COVID-19 severity

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dc.creatorKang, Chang Kyung
dc.creatorHan, Gi-Chan
dc.creatorKim, Minji
dc.creatorKim, Gwanghun
dc.creatorShin, Hyun Mu
dc.creatorSong, Kyoung-Ho
dc.creatorChoe, Pyoeng Gyun
dc.creatorPark, Wan Beom
dc.creatorKim, Eu Suk
dc.creatorKim, Hong Bin
dc.creatorKim, Nam-Joong
dc.creatorKim, Hang-Rae
dc.creatorOh, Myoung-don
dc.date.accessioned2020-07-23T17:21:05Z
dc.date.available2020-07-23T17:21:05Z
dc.date.created2020-08
dc.description.abstractenglishObjectives We hypothesized that immune response may contribute to progression of coronavirus disease-19 (COVID-19) at the second week of illness. Therefore, we compared cell-mediated immune (CMI) responses between severe and mild COVID-19 cases. Methods We examined peripheral blood mononuclear cells of laboratory-confirmed COVID-19 patients from their first and third weeks of illness. Severe pneumonia was defined as an oxygen saturation ≤93% at room air. Expressions of molecules related to T-cell activation and functions were analyzed by flow cytometry. Results The population dynamics of T cells at the first week were not different between the two groups. However, total numbers of CD4+ and CD8+ T cells tended to be lower in the severe group at the third week of illness. Expressions of Ki-67, PD-1, perforin, and granzyme B in CD4+ or CD8+ T cells were significantly higher in the severe group than in the mild group at the third week. In contrast to the mild group, the levels of their expression did not decrease in the severe group. Conclusions Severe COVID-19 had a higher degree of proliferation, activation, and cytotoxicity of T-cells at the late phase of illness without cytotoxic T-cell contraction, which might contribute to the development of severe COVID-19.spa
dc.format.extent9 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1016/j.ijid.2020.05.106spa
dc.identifier.issn1201-9712spa
dc.identifier.otherhttps://www.sciencedirect.com/science/article/pii/S1201971220304136spa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/11049
dc.publisherScience Directeng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCélula T citotóxicaspa
dc.subject.keywordCOVID-19spa
dc.subject.keywordSeverityspa
dc.subject.keywordContractionspa
dc.subject.keywordCytotoxic T cellspa
dc.subject.keywordPerforinspa
dc.subject.keywordGranzyme Bspa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titleAberrant hyperactivation of cytotoxic T-cell as a potential determinant of COVID-19 severityspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

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