The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice

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dc.creatorBao, Linlin
dc.creatorDeng, Wei
dc.creatorHuang, Baoying
dc.creatorGao, Hong
dc.creatorLiu, Jiangning
dc.creatorRen, Lili
dc.creatorWei, Qiang
dc.creatorYu, Pin
dc.creatorXu, Yanfeng
dc.creatorQi, Feifei
dc.creatorQu, Yajin
dc.creatorLi, Fengdi
dc.creatorLv, Qi
dc.creatorWang, Wenling
dc.creatorXue, Jing
dc.creatorGong, Shuran
dc.creatorLiu, Mingya
dc.creatorWang, Guanpeng
dc.creatorWang, Shunyi
dc.creatorSong, Zhiqi
dc.creatorZhao, Linna
dc.creatorLiu, Peipei
dc.creatorZhao, Li
dc.creatorYe, Fei
dc.creatorWang, Huijuan
dc.creatorZhou, Weimin
dc.creatorZhu, Na
dc.creatorZhen, Wei
dc.creatorYu, Haisheng
dc.creatorZhang, Xiaojuan
dc.creatorGuo, Li
dc.creatorChen, Lan
dc.creatorWang, Conghui
dc.creatorWang, Ying
dc.creatorWang, Xinming
dc.creatorXiao, Yan
dc.creatorSun, Qiangming
dc.creatorLiu, Hongqi
dc.creatorZhu, Fanli
dc.creatorMa, Chunxia
dc.creatorYan, Lingmei
dc.creatorYang, Mengli
dc.creatorHan, Jun
dc.creatorXu, Wenbo
dc.creatorTan, Wenjie
dc.creatorPeng, Xiaozhong
dc.creatorJin, Qi
dc.creatorWu, Guizhen
dc.creatorQin, Chuan
dc.date.accessioned2020-08-20T21:35:55Z
dc.date.available2020-08-20T21:35:55Z
dc.date.created2020-05-07
dc.description.abstractenglishSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19), which has become a public health emergency of international concern1. Angiotensin-converting enzyme 2 (ACE2) is the cell-entry receptor for severe acute respiratory syndrome coronavirus (SARS-CoV)2. Here we infected transgenic mice that express human ACE2 (hereafter, hACE2 mice) with SARS-CoV-2 and studied the pathogenicity of the virus. We observed weight loss as well as virus replication in the lungs of hACE2 mice infected with SARS-CoV-2. The typical histopathology was interstitial pneumonia with infiltration of considerable numbers of macrophages and lymphocytes into the alveolar interstitium, and the accumulation of macrophages in alveolar cavities. We observed viral antigens in bronchial epithelial cells, macrophages and alveolar epithelia. These phenomena were not found in wild-type mice infected with SARS-CoV-2. Notably, we have confirmed the pathogenicity of SARS-CoV-2 in hACE2 mice. This mouse model of SARS-CoV-2 infection will be valuable for evaluating antiviral therapeutic agents and vaccines, as well as understanding the pathogenesis of COVID-19.spa
dc.format.extent18 Páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1038/s41586-020-2312-yspa
dc.identifier.issn1476-4687spa
dc.identifier.otherhttps://www.nature.com/articles/s41586-020-2312-yspa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/12046
dc.language.isoengspa
dc.publisherNaturespa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.localAbierto (Texto Completo)spa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCOVID-19spa
dc.subject.keywordSARS-CoV-2spa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titleThe pathogenicity of SARS-CoV-2 in hACE2 transgenic micespa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

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