COVID-19 in persons with haematological cancers

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dc.creatorHe, Wenjuan
dc.creatorChen, Lei
dc.creatorChen, Li
dc.creatorYuan, Guolin
dc.creatorFang, Yun
dc.creatorChen, Wenlan
dc.creatorWu, Di
dc.creatorLiang, Bo
dc.creatorLu, Xiaoting
dc.creatorMa, Yanling
dc.creatorLi, Lei
dc.creatorWang, Hongxiang
dc.creatorChen, Zhichao
dc.creatorLi, Qiubai
dc.creatorGale, Robert Peter
dc.date.accessioned2020-07-17T15:14:38Z
dc.date.available2020-07-17T15:14:38Z
dc.date.created2020-04-24
dc.description.abstractenglishInfection with SARS-CoV-2, the cause of coronavirus infectious disease–19 (COVID-19), has caused a pandemic with >850,000 cases worldwide and increasing. Several studies report outcomes of COVID-19 in predominately well persons. There are also some data on COVID-19 in persons with predominately solid cancer but controversy whether these persons have the same outcomes. We conducted a cohort study at two centres in Wuhan, China, of 128 hospitalised subjects with haematological cancers, 13 (10%) of whom developed COVID-19. We also studied 226 health care providers, 16 of whom developed COVID-19 and 11 of whom were hospitalised. Co-variates were compared with the 115 subjects with haematological cancers without COVID-19 and with 11 hospitalised health care providers with COVID-19. There were no significant differences in baseline co-variates between subjects with haematological cancers developing or not developing COVID-19. Case rates for COVID-19 in hospitalised subjects with haematological cancers was 10% (95% Confidence Interval [CI], 6, 17%) compared with 7% (4, 12%; P = 0.322) in health care providers. However, the 13 subjects with haematological cancers had more severe COVID-19 and more deaths compared with hospitalised health care providers with COVID-19. Case fatality rates were 62% (32, 85%) and 0 (0, 32%; P = 0.002). Hospitalised persons with haematological cancers have a similar case rate of COVID-19 compared with normal health care providers but have more severe disease and a higher case fatality rate. Because we were unable to identify specific risk factors for COVID-19 in hospitalised persons with haematological cancers, we suggest increased surveillance and possible protective isolation.spa
dc.format.extent9 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1038/s41375-020-0836-7spa
dc.identifier.issn1476-5551 (online)spa
dc.identifier.otherhttps://www.nature.com/articles/s41375-020-0836-7spa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/10738
dc.publisherLeukemiaeng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjecthaematological cancersspa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titleCOVID-19 in persons with haematological cancersspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

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