Acute Encephalopathy Is Associated With Worse Outcomes In COVID-19 Patients

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dc.creatorShah, Vishank Arun
dc.creatorNalleballe, Krishna
dc.creatorZaghlouleh, Ezzat
dc.creatorOnteddu, Sanjeeva
dc.date.accessioned2020-09-22T15:01:02Z
dc.date.available2020-09-22T15:01:02Z
dc.date.created2020-08-25
dc.description.abstractenglishBackground Acute encephalopathy with COVID-19 has been reported in several studies but its impact on outcomes remains unclear. We hypothesized that hospitalized COVID-19 patients with encephalopathy have worse COVID-19 related outcomes. Methods We used TriNetX, with a large COVID-19 database, collecting real-time electronic medical records data. We included hospitalized COVID-19 patients since January 20, 2020 who had encephalopathy based on ICD-10 coding. We examined clinical outcomes comprising need for critical care services, intubation and mortality among these patients and compared it with patients without encephalopathy before and after propensity-score matching. Results Of 12,601 hospitalized COVID-19 patients, 1092 (8.7%) developed acute encephalopathy. Patients in the acute encephalopathy group were older (67 vs. 61 years) and had higher prevalence of medical co-morbidities including obesity, hypertension, diabetes, heart disease, COPD, chronic kidney and liver disease among others. Before and after propensity score-matching for co-morbidities, patients with acute encephalopathy were more likely to need critical care services (35.6% vs. 16.9%, p < 0.0001), intubation (19.5% vs. 6.0%, p<0.0001) and had higher 30-day mortality (24.3% vs. 17.9%, p 0.0002). Conclusion Among hospitalized COVID-19 patients, acute encephalopathy is common and more likely to occur in patients with medical co-morbidities and are more likely to need critical care, intubation and have higher 30-day mortality even after adjusting for age and underlying medical co-morbidities.spa
dc.format.extent19 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1016/j.bbih.2020.100136spa
dc.identifier.issn2666-3546spa
dc.identifier.otherhttps://www.sciencedirect.com/science/article/pii/S2666354620301010?via%3Dihub#!spa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/13555
dc.language.isospaspa
dc.publisherBrain, Behavior, & Immunity - Healthspa
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccessspa
dc.rights.localAcceso restringidospa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectoutcomesspa
dc.subjectencephalopathyspa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titleAcute Encephalopathy Is Associated With Worse Outcomes In COVID-19 Patientsspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

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