Single-Domain Antibodies: Biology, Engineering and Emerging Applications

Henry, Kevin A.; MacKenzie, C. Roger

doi:10.3389/978-2-88945-432-7

Single-Domain Antibodies: Biology, Engineering and Emerging Applications

dc.creator	Henry, Kevin A.
dc.creator	MacKenzie, C. Roger
dc.date.accessioned	2020-10-05T22:06:38Z
dc.date.available	2020-10-05T22:06:38Z
dc.date.created	2018-11-16
dc.description.abstractenglish	Single-domain antibodies (sdAbs) represent the minimal antigen binding-competent form of the immunoglobulin domain and have unique properties and applications. SdAbs are naturally produced as the variable domains of the heavy chain-only antibodies of camelid ruminants and cartilaginous fishes, but can also be engineered synthetically from autonomous human or mouse VH or VL domains. The scope of this research topic and associated e-book covers current understanding and new developments in (i) the biology, immunology and immunogenetics of sdAbs in camelids and cartilaginous fishes, (ii) strategies for sdAb discovery, (iii) protein engineering approaches to increase the solubility, stability and antigen-binding affinity of sdAbs and (iv) specialized applications of sdAbs in areas such diagnostics, imaging and therapeutics.	spa
dc.format.extent	338 páginas	spa
dc.format.mimetype	application/pdf	spa
dc.identifier.doi	10.3389/978-2-88945-432-7
dc.identifier.isbn	9782889454327
dc.identifier.issn	16648714
dc.identifier.other	https://www.frontiersin.org/research-topics/5098/single-domain-antibodies-biology-engineering-and-emerging-applications
dc.identifier.uri	https://hdl.handle.net/20.500.12010/14215
dc.language.iso	eng	spa
dc.publisher	Frontiers Media SA	spa
dc.relation.references	Henry, K. A., MacKenzie, C. R., eds. (2018). Single-Domain Antibodies: Biology, Engineering and Emerging Applications. Lausanne: Frontiers Media. doi: 10.3389/978-2-88945-432-7
dc.rights.accessrights	info:eu-repo/semantics/openAccess	spa
dc.rights.creativecommons	https://creativecommons.org/licenses/by/4.0/
dc.rights.local	Abierto (Texto Completo)	spa
dc.subject	Medicine (General)	spa
dc.subject	Allergy and Immunology	spa
dc.subject	Single	spa
dc.subject.keyword	Therapeutic antibody	spa
dc.subject.keyword	Diagnostic antibody	spa
dc.subject.lemb	Domain antibody	spa
dc.subject.lemb	Antibody discovery	spa
dc.subject.lemb	Antibody engineering	spa
dc.title	Single-Domain Antibodies: Biology, Engineering and Emerging Applications	spa
dc.type.coar	http://purl.org/coar/resource_type/c_2f33	spa
dc.type.local	Libro	spa

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Facultad de Ciencias Naturales e Ingeniería