Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

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dc.creatorBharath, Leena P.
dc.creatorAgrawal, Madhur
dc.creatorMcCambridge, Grace
dc.creatorNicholas, Dequina A.
dc.creatorHasturk, Hatice
dc.creatorLiu, Jing
dc.creatorLiu, Rui
dc.creatorGuo, Zhenheng
dc.creatorDeeney, Jude
dc.creatorApovian, Caroline M.
dc.creatorSnyder-Cappione, Jennifer
dc.creatorHawk, Gregory S.
dc.creatorFleeman, Rebecca M.
dc.creatorPihl, Riley M.F.
dc.creatorThompson, Katherine
dc.creatorBelkina, Anna C.
dc.creatorCui, Licong
dc.creatorNikolajczyk, Barbara S.
dc.date.accessioned2020-07-21T16:38:48Z
dc.date.available2020-07-21T16:38:48Z
dc.date.created2020-07-07
dc.description.abstractenglishAge is a non-modifiable risk factor for the inflammation that underlies age-associated diseases; thus, anti-inflammaging drugs hold promise for increasing health span. Cytokine profiling and bioinformatic analyses showed that Th17 cytokine production differentiates CD4+ T cells from lean, normoglycemic older and younger subjects, and mimics a diabetes-associated Th17 profile. T cells from older compared to younger subjects also had defects in autophagy and mitochondrial bioenergetics that associate with redox imbalance. Metformin ameliorated the Th17 inflammaging profile by increasing autophagy and improving mitochondrial bioenergetics. By contrast, autophagy-targeting siRNA disrupted redox balance in T cells from young subjects and activated the Th17 profile by activating the Th17 master regulator, STAT3, which in turn bound IL-17A and F promoters. Mitophagy-targeting siRNA failed to activate the Th17 profile. We conclude that metformin improves autophagy and mitochondrial function largely in parallel to ameliorate a newly defined inflammaging profile that echoes inflammation in diabetes.spa
dc.format.extent19 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1016/j.cmet.2020.04.015spa
dc.identifier.issn1550-4131spa
dc.identifier.otherhttps://www.sciencedirect.com/science/article/pii/S1550413120301972#kwrds0010spa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/10863
dc.publisherCell Metabolismeng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectinflammagingspa
dc.subjectT cellsspa
dc.subjectmetforminspa
dc.subjectautophagyspa
dc.subjectmitochondriaspa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titleMetformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammationspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

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