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SARS-CoV-2 in children: spectrum of disease, transmission and immunopathological underpinnings

Williams, Phoebe C.M.; Howard-Jones, Annaleise R.; Hsu, Peter; Palasanthiran, Pamela; Gray, Paul E.; McMullan, Brendan J.; Britton, Philip N.; Bartlett, Adam W.

As the SARS-CoV-2 pandemic unfolds across the globe, consistent themes are emerging with regard to aspects of SARS-CoV-2 infection and its associated disease entities in children. Overall, children appear to be less ...

Review on the potential action mechanisms of Chinese medicines in treating Coronavirus Disease 2019 (COVID-19)

Huang, Yu-Feng; Bai, Chen; He, Fan; Xie, Ying; Zhou, Hua

The Coronavirus Disease 2019 (COVID-19) has been declared as a global pandemic, but specific medicines and vaccines are still being developed. In China, interventional therapies with traditional Chinese medicine for COVID-19 ...

ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID-19

Dong, Mengzhen; Zhang, Jie; Ma, Xuefeng; Tan, Jie; Chen, Lizhen; Liu, Shousheng; Xin, Yongning; Zhuang, Likun

At the end of 2019, the coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in China. Currently, it is breaking out globally and posing a serious threat ...

COVID-19 and Sex Differences: Mechanisms and Biomarkers

Haitao, Tu; Vermunt, Jane; Abeykoon, Jithma; Ghamrawi, Ranine; Gunaratne, Madugodaralalage; Jayachandran, Muthuvel; Narang, Kavita; Parashuram, Santosh; Suvakov, Sonja; Garovic, Vesna

Men are consistently overrepresented in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, and COVID (COrona- VIrus-Disease)-19 severe outcomes, including higher fatality rates. These differences are ...

Convalescent plasma: A possible treatment protocol for COVID- 19 patients suffering from diabetes or underlying liver diseases

Yashwantrao Pawar, Ashish; Prashant Hiray, Apoorva; Devidas Sonawane, Deepak; Sudhakar Bhambar, Rajendra; Vishram Derle, Deelip; Suresh Ahire, Yogesh

Background & Aim: As on date, no specific treatment is available for devastating COVID-19 (SARS-CoV-2) infection. This pandemic viral infection has affected over 200 countries within a very short time and created a ...

Interactions between antihyperglycemic drugs and the reninangiotensin system: Putative roles in COVID-19. A mini-review

Nakhleh, Afif

Background: Diabetes mellitus is associated with a more severe course of coronavirus disease 2019 (COVID-19). The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes angiotensinconverting enzyme II (ACE2) ...

Potential role of ACE2-related microRNAs in COVID-19-associated nephropathy

Widiasta, Ahmedz; Sribudiani, Yunia; Nugrahapraja, Husna; Hilmanto, Dany; Sekarwana, Nanan; Rachmadi, Dedi

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is responsible for coronavirus disease (COVID-19), potentially have severe kidney adverse effects. This organ expressed angiotensin-converting enzyme ...

SARS-CoV-2 Infection and COVID-19 During Pregnancy: A Multidisciplinary Review

Narang, Kavita; Enninga, Elizabeth Ann L.; Gunaratne, Madugodaralalage D.S. K.; Ibirogba, Eniola R.; Trad, Ayssa Teles A.; Elrefaei, Amro; Theiler, Regan N.; Ruano, Rodrigo; Szymanski, Linda M.; Chakraborty, Rana; Phil, D.; Garovic, Vesna D.

The global pandemic of SARS-CoV-2, the cause of Coronavirus disease 2019 (COVID-19), has been associated with worse outcomes in several patient populations, including the elderly and those with chronic comorbidities. ...

Diabetes and metabolic syndrome as risk factors for COVID-19

Marhl, Marko; Grubelnik, Vladimir; Magdic, Marsa; Markovic, Rene

Background and aims: Clinical evidence exists that patients with diabetes are at higher risk for Coronavirus disease 2019 (COVID-19). We investigated the physiological origins of this clinical observation linking diabetes ...

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response

Astuti, Indwiani; Ysrafil

Background and aim: As a result of its rapid spread in various countries around the world, on March 11, 2020, WHO issued an announcement of the change in coronavirus disease 2019 status from epidemic to pandemic disease. ...