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Beneficial non-anticoagulant mechanisms underlying heparin treatment of COVID-19 patients
Coronavirus disease-2019 (COVID-19) is associated with severe inflammation in mainly the lung, and kidney.
Reports suggest a beneficial effect of the use of heparin/low molecular weight heparin (LMWH) on mortality
in ...
Coagulation dysfunction in COVID-19: the interplay between inflammation, viral infection and the coagulation system
COVID-19 is a new pandemic, caused by Severe Acute Respiratory Syndrome-CoronaVirus-2 (SARS-Cov2)
infection and characterized by a broad spectrum of clinical manifestations.
Inflammation and the innate immune system have ...
The possible mechanisms of action of 4-aminoquinolines (chloroquine/ hydroxychloroquine) against Sars-Cov-2 infection (COVID-19): A role for iron homeostasis?
The anti-malarial drugs chloroquine (CQ) and primarily the less toxic hydroxychloroquine (HCQ) are currently
used to treat autoimmune diseases for their immunomodulatory and anti-thrombotic properties. They have also
been ...
Sars-CoV-2 in pregnancy: Why is it better than expected?
In December 2019, a novel coronavirus (Sars-CoV-2) was first reported in Wuhan, in the Hubei
province of China and was declared pandemic by the World Health Organization (WHO) on March
11, 2020. While data regarding ...
Emerging role of IL-6 and NLRP3 inflammasome as potential therapeutic targets to combat COVID-19: Role of lncRNAs in cytokine storm modulation
The world has witnessed a high morbidity and mortality caused by SARS-CoV-2, and global death toll is still
rising. Exaggerated inflammatory responses are thought to be more responsible for infiltrated immune cells
accumulation, ...
COVID-19 and Sex Differences: Mechanisms and Biomarkers
Men are consistently overrepresented in Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2) infection, and COVID (COrona- VIrus-Disease)-19 severe outcomes, including
higher fatality rates. These differences are ...
Thromboinflammation in COVID-19 acute lung injury
Since the initial description in 2019, the novel coronavirus SARS-Cov-2 infection (COVID-19) pandemic
has swept the globe. The most severe form of the disease presents with fever and shortness of breath,
which rapidly ...