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The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin

Xia, Shuai; Lan, Qiaoshuai; Su, Shan; Wang, Xinling; Xu, Wei; Liu, Zezhong; Zhu, Yun; Wang, Qian; Lu, Lu; Jiang, Shibo

Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

Xia, Shuai; Liu, Meiqin; Wang, Chao; Xu, Wei; Lan, Qiaoshuai; Feng, Siliang; Qi, Feifei; Bao, Linlin; Du, Lanying; Liu, Shuwen; Qin, Chuan; Sun, Fei; Shi, Zhengli; Zhu, Yun; Jiang, Shibo; Lu Lu

Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine

Tai, Wanbo; He, Lei; Pu, Jing; Zhang, Xiujuan; Voronin, Denis; Jiang, Shibo; Zhou, Yusen; Du, Lanying

From SARS-CoV to SARS-CoV-2: safety and broad-spectrum are important for coronavirus vaccine development

Ma, Cuiqing; Su, Shan; Wang, Jiachao; Wei, Lin; Du, Lanying; Jiang, Shibo

The global pandemic of COVID-19 caused by SARS-CoV-2 (also known as 2019-nCoV and HCoV-19) has posed serious threats to public health and economic stability worldwide, thus calling for development of vaccines against ...

Current development of COVID-19 diagnostics, vaccines and therapeutics

Zhang, Naru; Li, Chaoqun; Hu, Yue; Li, Kangchen; Liang, Jintian; Wang, Lili; Du, Lanying; Jiang, Shibo

A novel coronavirus, designated as SARS-CoV-2, first emerged in Wuhan City, Hubei Province, China, in late December 2019. The rapidly increasing number of cases has caused worldwide panic. In this review, we describe ...