G-Quadruplexes in RNA biology: recent advances and future directions
Date
2020Author
Dumas, Leïla
Herviou, Pauline
Dassi, Erik
Millevoi, Stefania
Metadata
Show full item recordAbstract
RNA G-quadruplexes (RG4s) are four-stranded structures known to control gene
expression mechanisms, from transcription to protein synthesis, and DNArelated processes. Their potential impact on RNA biology allows these structures
to shape cellular processes relevant to disease development, making their
targeting for therapeutic purposes an attractive option. We review here the
current knowledge on RG4s, focusing on the latest breakthroughs supporting
the notion of transient structures that fluctuate dynamically in cellulo, their
interplay with RNA modifications, their role in cell compartmentalization, and
their deregulation impacting the host immune response. We emphasize RG4-
binding proteins as determinants of their transient conformation and effectors
of their biological functions.
Palabras clave
G-Quadruplexes; RNA biologyLink to resource
https://doi.org/10.1016/j.tibs.2020.11.001Collections
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