Show simple item record

dc.contributor.advisorShalev, Idan
dc.contributor.advisorEbstein, Richard P.
dc.date.accessioned2020-11-19T16:36:08Z
dc.date.available2020-11-19T16:36:08Z
dc.date.created2015
dc.identifier.isbn978-2-88919-407-0
dc.identifier.urihttp://hdl.handle.net/20.500.12010/15813
dc.description.abstractIntranasal oxytocin: potential therapeutic regulation of brain function in psychiatric illness. Several important aspects of intranasally delivered OT (IN OT) treatment of brain-based illness are represented. One potential way that IN OT may cross the blood-brain barrier and cause central effects is represented: directly via extraneuronal/perineuronal routes along trigeminal or olfactory nerve pathways. Other mechanisms of entry (bulk flow, lymphatic channels, intraneuronal transport, active or passive transport from vasculature) are discussed in references and the text. IN OT may cause some of its central effects by stimulating the endogenous OT system, which secretes OT into the peripheral circulation (right pullout), and has both direct, “wired” and diffusion-mediated central effects. Through these mechanisms, IN OT impacts the function of amygdala-anchored connectivity networks in normal, as well as important brain regions (amygdala, insula, anterior cingulate, medial prefrontal cortex) in patients with psychiatric illness. For simplicity, not all brain areas impacted by OT are shown. For more details, see review by MacDonald and Feifel in Part A: Helping oxytocin deliver- considerations in the development of oxytocin-based therapeutics for brain disorders.spa
dc.format.extent96 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherFrontiersspa
dc.subjectSocial hormonesspa
dc.titleSocial hormones and human behavior: what do we know and where do we go from herespa
dc.subject.lembSociogenómicaspa
dc.subject.lembGenómicaspa
dc.subject.lembCiencias socialesspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doi10.3389/978-2-88919-407-0
dc.type.coarhttp://purl.org/coar/resource_type/c_2f33spa


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record