Prevention and treatment of COVID-19: focus on interferons, chloroquine/hydroxychloroquine, azithromycin, and vaccine
Fecha
2020Autor
Bakadia, Bianza Moise
He, Feng
Souho, Tiatou
Lamboni, Lallepak
Wajid Ullah, Muhammad
Boni, Biaou Ode
Qaed Ahmed, Abeer Ahmed
Mukole, Biampata Mutu
Yang, Guang
Resumen
The ongoing pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) has drawn the attention of researchers and clinicians from several disciplines and sectors
who are trying to find durable solutions both at preventive and treatment levels. To date, there is
no approved effective treatment or vaccine available to control the coronavirus disease-2019
(COVID-19). The preliminary in vitro studies on viral infection models showed potential antiviral
activities of type I and III interferons (IFNs), chloroquine (CQ)/hydroxychloroquine (HCQ), and
azithromycin (AZM); however, the clinical studies on COVID-19 patients treated with CQ/HCQ
and AZM led to controversies in different regions due to their adverse side effects, as well as their
combined treatment could prolong the QT interval. Interestingly, the treatment with type I IFNs
showed encouraging results. Moreover, the different preliminary reports of COVID-19 candidate
vaccines showcase promising results by inducing the production of a high level of neutralizing
antibodies (NAbs) and specific T cell-mediated immune response in almost all participants. The
present review aims to summarize and analyze the recent progress evidence concerning the use of
IFNs, CQ/HCQ, and AZM for the treatment of COVID-19. The available data on immunization options to prevent the COVID-19 are also analyzed with the aim to present the promising options
which could be investigated in future for sustainable control of the pandemic.
Palabras clave
COVID-19; Treatment; Interferons; Chloroquine/hydroxychloroquine; Azithromycin; VaccineEnlace al recurso
https://doi.org/10.1016/j.biopha.2020.111008Colecciones
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