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dc.creatorSchütz, Desiree
dc.creatorRuiz-Blanco, Yasser B.
dc.creatorMünch, Jan
dc.creatorKirchhoff, Frank
dc.creatorSanchez-Garcia, Elsa
dc.creatorMüller, Janis A.
dc.date.accessioned2020-11-17T14:51:27Z
dc.date.available2020-11-17T14:51:27Z
dc.date.created2020
dc.identifier.issn0169-409Xspa
dc.identifier.otherhttps://doi.org/10.1016/j.addr.2020.11.007spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/15714
dc.description.abstractTo date, no effective vaccines or therapies are available against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pandemic agent of coronavirus disease 2019 (COVID-19). Due to their safety, efficacy and specificity, peptide inhibitors hold great promise for the treatment of newly emerging viral pathogens. Based on the known structures of viral proteins and their cellular targets, antiviral peptides can be rationally designed and optimized. The resulting peptides may be highly specific for their respective targets and particular viral pathogens or exert broad antiviral activity. Here, we summarize the current status of peptides inhibiting SARS-CoV-2 entry and outline the strategies used to design peptides targeting the ACE2 receptor or the viral Spike protein and its activating proteases furin, transmembrane serine protease 2 (TMPRSS2), or cathepsin L. In addition, we present approaches used against related viruses such as SARS-CoV-1 that might be implemented for inhibition of SARS-CoV-2 infection.spa
dc.format.extent70 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherAdvanced Drug Delivery Reviewsspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectPeptide drugspa
dc.subjectCOVID-19spa
dc.subjectCoronavirusspa
dc.subjectFusionspa
dc.subjectAntiviralspa
dc.titlePeptide and peptide-based inhibitors of SARS-CoV-2 entryspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1016/j.addr.2020.11.007spa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa


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