Can the coronavirus infection penetrates the brain resulting in sudden anosmia followed by severe neurological disorders?
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Abstract
Serious of unpredictable drawbacks of Coronavirus 2019 (COVID-19) infectious
disease caused by SARS-COV-2 on the nervous system, have been widely noticed
among the huge number of infected people. It was found that this type of newly
revolving pandemic infection mainly infects the human respiratory tract causing
mild to moderate symptoms, however, the hidden door side of COVID-19 is via
penetrating the brain, revealing a huge threat especially to elderly people who are
more susceptible to its severe side effects and even death to more extent. Almost
80% of COVID-19 patients suffer from severe neurological manifestations
including dizziness, headache, unconscious, irritability, dysfunction in smell, and
taste accompanied by muscle fatigue.
Herein, we are trying to address the direct neuroinvasive pathway of COVID-19
into human brain cells which is mainly through the olfactory route leading to longterm
neurological complications. In addition to highlighting the ability of COVID-
19 infection to intensify a pre-existing AD to a more prominent severe stage. The
other thing to emphasize is whether AD patients with a highly prominent activation
of local immune responses are more or less exposed to getting infected with
COVID-19. Along with underlying the hypothesis that the susceptibility to
COVID-19 infection may lead to a future risk for neurodegenerative diseases
including Alzheimer’s disease (AD).
Link to resource
https://doi.org/10.1016/j.ensci.2020.100290Collections
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