Characterization of neonates born to mothers with SARS-CoV-2 infection: review and meta-analysis
Rabenau, Holger F.
Raimann, Florian J.
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Objective: Characterization of neonates born to mothers with SARS-CoV-2 infection has been partially carried out. There has been no systematic review providing a holistic neonatal presentation including possible vertical transmission. Study design: A systematic literature search was performed using PubMed, Google Scholar and Web of Science up to June, 6 2020. Studies on neonates born to mothers with SARS7 CoV-2 infection were included. A binary random effect model was used for prevalence and 95% confidence interval. Results: 32 studies involving 261 neonates were included in meta-analysis. Most neonates born to infected mothers did not show any clinical abnormalities (80.4%). Clinical features were dyspnea in 11 (42.3%) and fever in 9 newborns (19.1%). Of 261 neonates, 120 neonates were tested for infection, of whom 12 (10.0%) tested positive. Swabs from placenta, cord blood and vaginal secretion were negative. Conclusions: Neonates are mostly non affected by the mother`s SARS-CoV-2 infection. The risk of vertical transmission is low.
Link to resourcehttps://doi.org/10.1016/j.pedneo.2020.10.001
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