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dc.creatorKostoff, Ronald N.
dc.creatorKanduc, Darja
dc.creatorPorter, Alan L.
dc.creatorShoenfeld, Yehuda
dc.creatorCalina, Daniela
dc.creatorBriggs, Michael B.
dc.creatorSpandidos, Demetrios A.
dc.creatorTsatsakis, Aristidis
dc.date.accessioned2020-11-04T14:05:56Z
dc.date.available2020-11-04T14:05:56Z
dc.date.created2020
dc.identifier.issn2214-7500spa
dc.identifier.otherhttps://doi.org/10.1016/j.toxrep.2020.10.016spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/15297
dc.description.abstractA degraded/dysfunctional immune system appears to be the main determinant of serious/fatal reaction to viral infection (for COVID-19, SARS, and influenza alike). There are four major approaches being employed or considered presently to augment or strengthen the immune system, in order to reduce adverse effects of viral exposure. The three approaches that are focused mainly on augmenting the immune system are based on the concept that pandemics/outbreaks can be controlled/prevented while maintaining the immune-degrading lifestyles followed by much of the global population. The fourth approach is based on identifying and introducing measures aimed at strengthening the immune system intrinsically in order to minimize future pandemics/outbreaks. Specifically, the four measures are: 1) restricting exposure to virus; 2) providing reactive/tactical treatments to reduce viral load; 3) developing vaccines to prevent, or at least attenuate, the infection; 4) strengthening the immune system intrinsically, by a) identifying those factors that contribute to degrading the immune system, then eliminating/reducing them as comprehensively, thoroughly, and rapidly as possible, and b) replacing the eliminated factors with immune-strengthening factors. This paper focuses on vaccine safety. A future COVID-19 vaccine appears to be the treatment of choice at the national/international level. Vaccine development has been accelerated to achieve this goal in the relatively near-term, and questions have arisen whether vaccine safety has been/is being/will be compromised in pursuit of a shortened vaccine development time. There are myriad mechanisms related to vaccine-induced, and natural infection-induced, infections that could adversely impact vaccine effectiveness and safety. This paper summarizes many of those mechanisms.spa
dc.format.extent42 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherToxicology Reportsspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectPandemicspa
dc.subjectVaccine Safetyspa
dc.subjectAutoimmunityspa
dc.subjectMolecular Mimicryspa
dc.subjectCross Reactivityspa
dc.subjectImmune Interferencespa
dc.titleVaccine- and natural infection-induced mechanisms that could modulate vaccine safetyspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1016/j.toxrep.2020.10.016spa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa


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