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dc.creatorBeddingfield, Brandon J.
dc.creatorIwanaga, Naoki
dc.creatorChapagain, Prem P.
dc.creatorZheng, Wenshu
dc.creatorRoy, Chad J.
dc.creatorHu, Tony Y.
dc.creatorKolls, Jay K.
dc.creatorBix, Gregory J.
dc.date.accessioned2020-10-21T17:00:36Z
dc.date.available2020-10-21T17:00:36Z
dc.date.created2020
dc.identifier.issn2452-302Xspa
dc.identifier.otherhttps://doi.org/10.1016/j.jacbts.2020.10.003spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/14657
dc.description.abstractMany efforts to design and screen therapeutics for the current severe acute respiratory syndrome coronavirus (SARS-CoV-2) pandemic have focused on inhibiting viral host cell entry by disrupting ACE2 binding with the SARS-CoV-2 spike protein. This work focuses on the potential to inhibit SARS-CoV-2 entry through a hypothesized α5β1 integrin-based mechanism, and indicates that inhibiting the spike protein interaction with α5β1 integrin (+/- ACE2), and the interaction between α5β1 integrin and ACE2 using a novel molecule ATN-161 represents a promising approach to treat COVID-19.spa
dc.format.extent24 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherJACC: Basic to Translational Sciencespa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCOVID-19spa
dc.subjectSARS-CoV-2spa
dc.subjectACE2spa
dc.subjectAlpha5beta1 integrinspa
dc.subjectATN-161spa
dc.subjectTherapeuticspa
dc.subjectHost-cell entryspa
dc.subjectViral spike proteinspa
dc.subjectReceptor binding domainspa
dc.titleThe integrin binding peptide, atn-161, as a novel therapy for SARS-CoV-2 infectionspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1016/j.jacbts.2020.10.003spa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa


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