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dc.creatorBhattacharjee, Anindya S.
dc.creatorJoshi, Samir V.
dc.creatorNaik, Shilpa
dc.creatorSangle, Shashikala
dc.creatorAbraham, Nixon M.
dc.date.accessioned2020-10-16T19:48:16Z
dc.date.available2020-10-16T19:48:16Z
dc.date.created2020
dc.identifier.issn2589-5370spa
dc.identifier.otherhttps://doi.org/10.1016/j.eclinm.2020.100575spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/14525
dc.description.abstractBackground: COVID-19 threatens the global community because a large fraction of infected people are asymptomatic, yet can effectively transmit SARS-CoV-2. Finding and isolating these silent carriers is a crucial step in confining the spread of the disease. A sudden loss of the sense of smell has been self-reported by COVID-19 patients across different countries, consistent with expression of the molecular factors mediating SARS-CoV-2 uptake into human olfactory epithelial supporting cells. However, precise quantification of olfactory loss in asymptomatic COVID-19 carriers is missing to date. Methods: To quantify olfactory functions in asymptomatic COVID-19 patients, we designed an olfactoryaction meter that determines detectability indices at different odor concentrations and an olfactory matching accuracy score using monomolecular odors. The optimization of test parameters allowed us to reliably and accurately assess olfactory deficits in a patient within 20 minutes. Findings: Measurement of detection indices at low concentrations revealed a 50% reduction in asymptomatic COVID-19 carriers. Further, patients with better detection scores showed significantly reduced olfactory matching accuracies compared to normal healthy subjects. Our quantification of olfactory loss, considering all parameters, identified 82% of the asymptomatic SARS-CoV-2 carriers with olfactory deficits. However, on subjective evaluation, only 15% of the patients noticed a compromised ability to smell. Interpretation: Compromised olfactory fitness can serve as a strong basis for identifying asymptomatic COVID-19 patients. Detailed design specifications and protocols provided here should enable the development of a sensitive, fast, and economical screening strategy that can be administered to large populations to prevent the rapid spread of COVID-19spa
dc.format.extent13 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherEClinicalMedicinespa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCOVID-19 carriersspa
dc.subjectAccurately detects asymptomaticspa
dc.titleQuantitative assessment of olfactory dysfunction accurately detects asymptomatic COVID-19 carriersspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1016/j.eclinm.2020.100575spa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa


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