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dc.creatorLu, Shuaiyao
dc.creatorZhao, Jingjing
dc.creatorDong, Jiebin
dc.creatorLiu, Hongqi
dc.creatorZhu, Yinhua
dc.creatorLi, Honggang
dc.creatorLiu, Liping
dc.creatorYang, Yun
dc.creatorSun, Shicheng
dc.creatorSong, Yifan
dc.creatorZhao, Yuan
dc.creatorShe, Ruiping
dc.creatorLuo, Tuoping
dc.creatorDeng, Hongkui
dc.creatorPeng, Xiaozhong
dc.date.accessioned2020-10-14T14:35:49Z
dc.date.available2020-10-14T14:35:49Z
dc.date.created2020
dc.identifier.issn1001-0602spa
dc.identifier.otherhttps://doi.org/10.1038/s41422-020-00414-4spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/14452
dc.description.abstractThe COVID-19 pandemic caused by the SARS-CoV-2 virus has caused a significant public health crisis worldwide. Recent studies show that excessive inflammatory response is critical for SARSCoV-2 pathogenesis and COVID-19 severity,1 which can lead to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).2 One major factor for acute inflammation in SARS-CoV-2 infection is the inflammatory macrophages, which has been considered important for the production of large amounts of proinflammatory cytokines.3 Autopsy identified an intense infiltration of macrophages in the lung tissues of fatal COVID-19 patients.4 Furthermore, single-cell RNA sequencing (scRNA-seq) showed a higher proportion of macrophages presenting in bronchoalveolar lavage fluid (BALF) of severe COVID-19 patients.5 Consistent with studies of SARS-CoV-2, infiltration and accumulation of macrophages in the lung were also found in other coronavirus diseases.6 Depletion of macrophages protected mice from lethal SARS-CoV infection, highlighting the important roles of macrophages in coronavirus-induced symptoms.7 Therefore, targeting macrophages to regulate hyperinflammation in SARSCoV-2 infection could be an effective strategy to treat COVID-19 patients.spa
dc.format.extent4 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherCell reasearchspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectSARS-CoV-2-infectedspa
dc.subjectEffective treatmentspa
dc.subjectAttenuating inflammationspa
dc.titleEffective treatment of SARS-CoV-2-infected rhesus macaques by attenuating inflammationspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1038/s41422-020-00414-4spa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa


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