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dc.creatorNienhold, Ronny
dc.creatorCiani, Yari
dc.creatorKoelzer, Viktor H.
dc.creatorTzankov, Alexandar
dc.creatorHaslbauer, Jasmin D.
dc.creatorMenter, Thomas
dc.creatorSchwab, Nathalie
dc.creatorHenkel, Maurice
dc.creatorFrank, Angela
dc.creatorZsikla, Veronika
dc.creatorWilli, Niels
dc.creatorKempf, Werner
dc.creatorHoyler, Thomas
dc.creatorBarbareschi, Mattia
dc.creatorMoch, Holger
dc.creatorTolnay, Markus
dc.creatorCathomas, Gieri
dc.creatorDemichelis, Francesca
dc.creatorJunt, Tobias
dc.creatorMertz, Kirsten D.
dc.date.accessioned2020-10-13T19:44:50Z
dc.date.available2020-10-13T19:44:50Z
dc.date.created2020
dc.identifier.issn2041-1723spa
dc.identifier.otherhttps://doi.org/10.1038/s41467-020-18854-2spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/14420
dc.description.abstractCoronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has grown to a worldwide pandemic with substantial mortality. Immune mediated damage has been proposed as a pathogenic factor, but immune responses in lungs of COVID-19 patients remain poorly characterized. Here we show transcriptomic, histologic and cellular profiles of post mortem COVID-19 (n = 34 tissues from 16 patients) and normal lung tissues (n = 9 tissues from 6 patients). Two distinct immunopathological reaction patterns of lethal COVID-19 are identified. One pattern shows high local expression of interferon stimulated genes (ISGhigh) and cytokines, high viral loads and limited pulmonary damage, the other pattern shows severely damaged lungs, low ISGs (ISGlow), low viral loads and abundant infiltrating activated CD8+ T cells and macrophages. ISGhigh patients die significantly earlier after hospitalization than ISGlow patients. Our study may point to distinct stages of progression of COVID-19 lung disease and highlights the need for peripheral blood biomarkers that inform about patient lung status and guide treatment.spa
dc.format.extent13 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherNature communicationsspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectImmunopathological profilesspa
dc.subjectAutopsy lungsspa
dc.subjectOVID-19spa
dc.titleTwo distinct immunopathological profiles in autopsy lungs of COVID-19spa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1038/s41467-020-18854-2spa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa


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