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dc.creatorZhao, Yuan
dc.creatorWang, Junbin
dc.creatorKuang, Dexuan
dc.creatorXu, Jingwen
dc.creatorYang, Mengli
dc.creatorMa, Chunxia
dc.creatorZhao, Siwen
dc.creatorLi, Jingmei
dc.creatorLong, Haiting
dc.creatorDing, Kaiyun
dc.creatorGao, Jiahong
dc.creatorLiu, Jiansheng
dc.creatorWang, Haixuan
dc.creatorLi, Haiyan
dc.creatorYang, Yun
dc.creatorYu, Wenhai
dc.creatorYang, Jing
dc.creatorZheng, Yinqiu
dc.creatorWu, Daoju
dc.creatorLu, Shuaiyao
dc.creatorLiu, Hongqi
dc.creatorPeng, Xiaozhong
dc.date.accessioned2020-10-13T17:34:05Z
dc.date.available2020-10-13T17:34:05Z
dc.date.created2020
dc.identifier.issn2045-2322spa
dc.identifier.otherhttps://doi.org/10.1038/s41598-020-72563-wspa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/14403
dc.description.abstractSince severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became a pandemic event in the world, it has not only caused huge economic losses, but also a serious threat to global public health. Many scientifc questions about SARS-CoV-2 and Coronavirus disease (COVID-19) were raised and urgently need to be answered, including the susceptibility of animals to SARS-CoV-2 infection. Here we tested whether tree shrew, an emerging experimental animal domesticated from wild animal, is susceptible to SARS-CoV-2 infection. No clinical signs were observed in SARS-CoV-2 inoculated tree shrews during this experiment except the increasing body temperature particularly in female animals. Low levels of virus shedding and replication in tissues occurred in all three age groups. Notably, young tree shrews (6 months to 12 months) showed virus shedding at the earlier stage of infection than adult (2 years to 4 years) and old (5 years to 7 years) animals that had longer duration of virus shedding comparatively. Histopathological examine revealed that pulmonary abnormalities were the main changes but mild although slight lesions were also observed in other tissues. In summary, tree shrew is less susceptible to SARS-CoV-2 infection compared with the reported animal models and may not be a suitable animal for COVID-19 related researches. However, tree shrew may be a potential intermediate host of SARS-CoV-2 as an asymptomatic carrier.spa
dc.format.extent9 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherScientific reportsspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectSusceptibilityspa
dc.subjectSARS‑CoV‑2spa
dc.subjectInfectionspa
dc.titleSusceptibility of tree shrew to SARS‐CoV‐2 infectionspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1038/s41598-020-72563-wspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa


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