Susceptibility of tree shrew to SARS‐CoV‐2 infection
Fecha
2020Autor
Zhao, Yuan
Wang, Junbin
Kuang, Dexuan
Xu, Jingwen
Yang, Mengli
Ma, Chunxia
Zhao, Siwen
Li, Jingmei
Long, Haiting
Ding, Kaiyun
Gao, Jiahong
Liu, Jiansheng
Wang, Haixuan
Li, Haiyan
Yang, Yun
Yu, Wenhai
Yang, Jing
Zheng, Yinqiu
Wu, Daoju
Lu, Shuaiyao
Liu, Hongqi
Peng, Xiaozhong
Resumen
Since severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became a pandemic event in the
world, it has not only caused huge economic losses, but also a serious threat to global public health.
Many scientifc questions about SARS-CoV-2 and Coronavirus disease (COVID-19) were raised and
urgently need to be answered, including the susceptibility of animals to SARS-CoV-2 infection. Here
we tested whether tree shrew, an emerging experimental animal domesticated from wild animal, is
susceptible to SARS-CoV-2 infection. No clinical signs were observed in SARS-CoV-2 inoculated tree
shrews during this experiment except the increasing body temperature particularly in female animals.
Low levels of virus shedding and replication in tissues occurred in all three age groups. Notably,
young tree shrews (6 months to 12 months) showed virus shedding at the earlier stage of infection
than adult (2 years to 4 years) and old (5 years to 7 years) animals that had longer duration of virus
shedding comparatively. Histopathological examine revealed that pulmonary abnormalities were the
main changes but mild although slight lesions were also observed in other tissues. In summary, tree
shrew is less susceptible to SARS-CoV-2 infection compared with the reported animal models and may
not be a suitable animal for COVID-19 related researches. However, tree shrew may be a potential
intermediate host of SARS-CoV-2 as an asymptomatic carrier.
Palabras clave
Susceptibility; SARS‑CoV‑2; InfectionEnlace al recurso
https://doi.org/10.1038/s41598-020-72563-wColecciones
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