dc.creator | Qin, Cheng | |
dc.creator | Wei, Yingxin | |
dc.creator | Lyu, Xiaoyu | |
dc.creator | Zhao, Bangbo | |
dc.creator | Feng, Yunlu | |
dc.creator | Li, Tianhao | |
dc.creator | Cao, Hongtao | |
dc.creator | Yang, Xiaoying | |
dc.creator | Zhou, Xingtong | |
dc.creator | Wang, Weibin | |
dc.creator | You, Lei | |
dc.creator | Wang, Yujun | |
dc.date.accessioned | 2020-10-13T16:25:45Z | |
dc.date.available | 2020-10-13T16:25:45Z | |
dc.date.created | 2020 | |
dc.identifier.issn | 2045-2322 | spa |
dc.identifier.other | https://doi.org/10.1038/s41598-020-73575-2 | spa |
dc.identifier.uri | http://hdl.handle.net/20.500.12010/14384 | |
dc.description.abstract | This study aimed to analyze aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio
in COVID-19 patients. After exclusion, 567 inpatients were included in this study and separated into
two groups according to their AST/ALT ratio on admission. Death was regarded as poor prognosis in
this study. Of 567 patients, 200 (35.3%) had AST/ALT≥ 1.38. Of the 200 patients, older age (median
age 60 years), myalgia (64 [32%] cases), fatigue (91 [45.5%] cases), some comorbidities and outcomes
were signifcantly diferent from patients with AST/ALT< 1.38. They also had worse chest computed
tomography (CT) fndings, laboratory results and severity scores. Levels of platelet count (OR
0.995, 95% CI [0.992–0.998]) and hemoglobin (OR 0.984, 95% CI [0.972–0.995]) were independently
associated with AST/ALT≥ 1.38 on admission. Furthermore, a high AST/ALT ratio on admission
was an independent risk factor for poor prognosis (OR 99.9, 95% CI [2.1–4280.5]). In subsequent
monitoring, both survivors and non-survivors showed decreased AST/ALT ratio during hospitalization.
In conclusion, high AST/ALT ratio might be the indication of worse status and outcomes in COVID-19
patients. | spa |
dc.format.extent | 10 páginas | spa |
dc.format.mimetype | application/pdf | spa |
dc.language.iso | eng | spa |
dc.publisher | Scientific reports | spa |
dc.source | reponame:Expeditio Repositorio Institucional UJTL | spa |
dc.source | instname:Universidad de Bogotá Jorge Tadeo Lozano | spa |
dc.subject | Aminotransferase | spa |
dc.subject | COVID‑19 | spa |
dc.subject | Patients | spa |
dc.title | High aspartate aminotransferase to alanine aminotransferase ratio on admission as risk factor for poor prognosis in COVID‑19 patients | spa |
dc.type.local | Artículo | spa |
dc.subject.lemb | Síndrome respiratorio agudo grave | spa |
dc.subject.lemb | COVID-19 | spa |
dc.subject.lemb | SARS-CoV-2 | spa |
dc.subject.lemb | Coronavirus | spa |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
dc.type.hasversion | info:eu-repo/semantics/acceptedVersion | spa |
dc.rights.local | Abierto (Texto Completo) | spa |
dc.identifier.doi | https://doi.org/10.1038/s41598-020-73575-2 | spa |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | spa |