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dc.creatorQin, Cheng
dc.creatorWei, Yingxin
dc.creatorLyu, Xiaoyu
dc.creatorZhao, Bangbo
dc.creatorFeng, Yunlu
dc.creatorLi, Tianhao
dc.creatorCao, Hongtao
dc.creatorYang, Xiaoying
dc.creatorZhou, Xingtong
dc.creatorWang, Weibin
dc.creatorYou, Lei
dc.creatorWang, Yujun
dc.date.accessioned2020-10-13T16:25:45Z
dc.date.available2020-10-13T16:25:45Z
dc.date.created2020
dc.identifier.issn2045-2322spa
dc.identifier.otherhttps://doi.org/10.1038/s41598-020-73575-2spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/14384
dc.description.abstractThis study aimed to analyze aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio in COVID-19 patients. After exclusion, 567 inpatients were included in this study and separated into two groups according to their AST/ALT ratio on admission. Death was regarded as poor prognosis in this study. Of 567 patients, 200 (35.3%) had AST/ALT≥ 1.38. Of the 200 patients, older age (median age 60 years), myalgia (64 [32%] cases), fatigue (91 [45.5%] cases), some comorbidities and outcomes were signifcantly diferent from patients with AST/ALT< 1.38. They also had worse chest computed tomography (CT) fndings, laboratory results and severity scores. Levels of platelet count (OR 0.995, 95% CI [0.992–0.998]) and hemoglobin (OR 0.984, 95% CI [0.972–0.995]) were independently associated with AST/ALT≥ 1.38 on admission. Furthermore, a high AST/ALT ratio on admission was an independent risk factor for poor prognosis (OR 99.9, 95% CI [2.1–4280.5]). In subsequent monitoring, both survivors and non-survivors showed decreased AST/ALT ratio during hospitalization. In conclusion, high AST/ALT ratio might be the indication of worse status and outcomes in COVID-19 patients.spa
dc.format.extent10 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherScientific reportsspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectAminotransferasespa
dc.subjectCOVID‑19spa
dc.subjectPatientsspa
dc.titleHigh aspartate aminotransferase to alanine aminotransferase ratio on admission as risk factor for poor prognosis in COVID‑19 patientsspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1038/s41598-020-73575-2spa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa


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