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dc.creatorTamouza, Ryad
dc.creatorKrishnamoorthy, Rajagopal
dc.creatorLeboyer, Marion
dc.date.accessioned2020-10-06T15:55:12Z
dc.date.available2020-10-06T15:55:12Z
dc.date.created2020
dc.identifier.issn0889-1591spa
dc.identifier.otherhttps://doi.org/10.1016/j.bbi.2020.09.033spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/14244
dc.description.abstractThe human leukocyte antigen (HLA) is a complex genetic system that encodes proteins which predominantly regulate immune/inflammatory processes. It can be involved in a variety of immuno-inflammatory disorders ranging from infections to autoimmunity and cancers. The HLA system is also suggested to be involved in neurodevelopment and neuroplasticity, especially through microglia regulation and synaptic pruning. Consequently, this highly polymorphic gene region has recently emerged as a major player in the etiology of several major psychiatric disorders, such as schizophrenia, autism spectrum disorder and bipolar disorder and with less evidence for major depressive disorders and attention deficit hyperactivity disorder. We thus review here the role of HLA genes in particular subgroups of psychiatric disorders and foresee their potential implication in future research. In particular, given the prominent role that the HLA system plays in the regulation of viral infection, this review is particularly timely in the context of the Covid-19 pandemic.spa
dc.format.extent31 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherBrain, Behavior, and Immunityspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectHuman Leukocyte Antigen (HLA)spa
dc.subjectImmunogeneticsspa
dc.subjectAncestral Haplotypes (AH)spa
dc.subjectMajor Psychiatric Disordersspa
dc.titleUnderstanding the genetic contribution of the Human Leukocyte Antigen sys‐ tem to common major psychiatric disorders in a world pandemic contextspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1016/j.bbi.2020.09.033spa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa


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