Hydroxychloroquine use in hospitalised patients with COVID-19: An observational matched cohort study
Fecha
2020Autor
Kalligeros, Markos
Shehadeh, Fadi
Atalla, Eleftheria
Mylona, Evangelia K.
Aung, Su
Pandita, Aakriti
Larkin, Jerry
Sanchez, Martha
Touzard-Romo, Francine
Brotherton, Amy
Shah, Rajeev
Cunha, Cheston B.
Mylonakis, Eleftherios
Resumen
Aim: To assess the efficacy and safety of hydroxychloroquine with or without azithromycin) in
hospitalized adult patients with COVID-19.
Methods: We utilized a hospital based prospective data registry. The primary end point was to assess the
impact of hydroxychloroquine with or without azithromycin, on outcome, length of hospitalization, and
time to clinical improvement. We utilized treatment effects with inverse-probability-weighting and Cox
proportional hazards models. All analyses accounted for age, gender, race, severity on admission, days
from symptoms onset and chronic comorbidities.
Results: 36 patients received hydroxychloroquine and were age- and sex-matched to 72 patients with
COVID-19 who received supportive care. Compared to supportive care, the use of HCQ did not shorten the
time to clinical improvement (+0.23 days; 95% CI: 1.8–2.3 days) nor did it shorten the duration of
hospital stay (+0.91 days; 95% CI: 1.1–2.9 days). Additionally, HCQ did not decrease the risk of COVID-19
in-hospital death (aHR 1.67; 95% CI: 0.29–9.36). Finally, we observed a slight QTc prolongation from a
baseline of 444 26 ms to 464 32 ms (meanSD) among patients receiving hydroxychloroquine with
or without azithromycin.
Conclusion: This study did not yield benefits from hydroxychloroquine use in patients with COVID-19 and
monitoring for adverse events is warranted. Nevertheless, the treatment was safely studied under the
guidance of an antimicrobial stewardship program.
Palabras clave
COVID-19; SARS-CoV-2; Hydroxychloroquine; QTc; Efficacy; SafetyEnlace al recurso
http://dx.doi.org/10.1016/j.jgar.2020.07.018Colecciones
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