Show simple item record

dc.creatorMu, Chenglin
dc.creatorSheng, Yifan
dc.creatorWang, Qian
dc.creatorAmin, Amr
dc.creatorLi, Xugang
dc.creatorXie, Yingqiu
dc.date.accessioned2020-10-01T15:38:52Z
dc.date.available2020-10-01T15:38:52Z
dc.date.created2020
dc.identifier.issn1756-4646spa
dc.identifier.otherhttps://doi.org/10.1016/j.jff.2020.104149spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/14081
dc.description.abstractRhizoma Polygonati (huangjing in Chinese, 黄精) is an herb-homology-food used as a component of alternative medicine treating COVID-19 in the current pandemic emergency in China but the mechanisms remain elusive. Here using TCMSP and Swiss Target Prediction databases to sort out the potential targets of the main chemical components and GenCLiP3, NCBI, and GeneCard databases to search for COVID-19 related targets, the chemical compound-target-pathway network was analyzed. Each component was molecularly docked with host cell target angiotensin converting enzyme II, SARS-CoV-2 targets Spike protein, RNA-dependent RNA polymerase, or 3CL hydrolase. Our results showed a higher affinity of the compound diosgenin and (+)-Syringaresinol-O-beta-D-glucoside binding to the three SARS-CoV-2 proteins compared to the other compounds tested. Thus, our data suggest that potential compounds in Rhizoma Polygonati may act on different targets and have a great potential in treatment of COVID-19.spa
dc.format.extent22 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherJournal of Functional Foodsspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectNetwork Pharmacologyspa
dc.subjectRhizoma Polygonatispa
dc.subjectMolecular Dockingspa
dc.subjectNew coronavirus pneumoniaspa
dc.subjectCOVID-19spa
dc.titlePotential compound from herbal food of rhizoma polygonati for treatment of COVID-19 analyzed by network pharmacology and molecular docking tech- nologyspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1016/j.jff.2020.104149spa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record