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dc.creatorChen, Yi
dc.creatorWang, Guan
dc.creatorOuyang, Liang
dc.date.accessioned2020-09-30T20:43:14Z
dc.date.available2020-09-30T20:43:14Z
dc.date.created2020
dc.identifier.issn2059-3635spa
dc.identifier.otherhttps://doi.org/10.1038/s41392-020-00291-8spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/14043
dc.description.abstractRecently, Dai W et al. published a study on Science,1 in which the two lead compounds 11a and 11b were designed and synthesized based on the features of a key enzyme Mpro of SARSCoV-2 (Fig. 1). In particular, compound 11a is a potential drug candidate for coronavirus disease 2019 (COVID-19) with strong anti-SARS-CoV-2 infection activity, good pharmacokinetics characteristics, and low toxicity. Since December 2019, the outbreak of COVID-19 caused by SARS-CoV-22 has caused a serious global public health emergency. So far, the global epidemic is still in the outbreak stage, and the number of new confirmed cases every day has exceeded 100,000 for several days. At present, the main drugs used clinically include interferon-alpha, lopinavir/ritonavir, ribavirin, arbidol, etc. However, these drugs are facing huge controversy due to the large side effects or the lack of clinical verifications of the therapeutic effects.3 Therefore, clarifying the origin and pathogenesis of pneumonia and decoding the key targets against SARS-CoV-2 are the cornerstone to design and discover safe and effective antivirus drugs.spa
dc.format.extent2 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherSignal Transduction and Targeted Therapyspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectTargeting Mprospa
dc.subjectAnti SARS-CoV-2spa
dc.subjectDrug discoveryspa
dc.titlePromising inhibitors targeting Mpro: an ideal strategy for anti- SARS-CoV-2 drug discoveryspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1038/s41392-020-00291-8spa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa


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