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dc.creatorChen, Xiangyu
dc.creatorPan, Zhiwei
dc.creatorYue, Shuai
dc.creatorYu, Fei
dc.creatorZhang, Junsong
dc.creatorYang, Yang
dc.creatorLi, Ren
dc.creatorLiu, Bingfeng
dc.creatorYang, Xiaofan
dc.creatorGao, Leiqiong
dc.creatorLi, Zhirong
dc.creatorLin, Yao
dc.creatorHuang, Qizhao
dc.creatorXu, Lifan
dc.creatorTang, Jianfang
dc.creatorHu, Li
dc.creatorZhao, Jing
dc.creatorLiu, Pinghuang
dc.creatorZhang, Guozhong
dc.creatorChen, Yaokai
dc.creatorDeng, Kai
dc.creatorYe, Lilin
dc.date.accessioned2020-09-30T20:16:42Z
dc.date.available2020-09-30T20:16:42Z
dc.date.created2020
dc.identifier.issn2059-3635spa
dc.identifier.otherhttps://doi.org/10.1038/s41392-020-00301-9spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/14039
dc.description.abstractCOVID-19 patients exhibit differential disease severity after SARS-CoV-2 infection. It is currently unknown as to the correlation between the magnitude of neutralizing antibody (NAb) responses and the disease severity in COVID-19 patients. In a cohort of 59 recovered patients with disease severity including severe, moderate, mild, and asymptomatic, we observed the positive correlation between serum neutralizing capacity and disease severity, in particular, the highest NAb capacity in sera from the patients with severe disease, while a lack of ability of asymptomatic patients to mount competent NAbs. Furthermore, the compositions of NAb subtypes were also different between recovered patients with severe symptoms and with mild-tomoderate symptoms. These results reveal the tremendous heterogeneity of SARS-CoV-2-specific NAb responses and their correlations to disease severity, highlighting the needs of future vaccination in COVID-19 patients recovered from asymptomatic or mild illness.spa
dc.format.extent6 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherSignal Transduction and Targeted Therapyspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectSARS-CoV-2-specificspa
dc.subjectDisease severity dictatesspa
dc.subjectCOVID-19spa
dc.titleDisease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19spa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1038/s41392-020-00301-9spa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa


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